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存储条件对阿拉伯胶和刺槐豆胶稳定性的影响。

Influence of Storage Conditions on the Stability of Gum Arabic and Tragacanth.

机构信息

Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland.

Doctoral School, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland.

出版信息

Molecules. 2022 Feb 23;27(5):1510. doi: 10.3390/molecules27051510.

DOI:10.3390/molecules27051510
PMID:35268614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8911758/
Abstract

Storage conditions should be chosen so that they do not affect the action and stability of the active pharmaceutical substance (API), and excipients used in pharmacy. UV irradiation, increased temperature, and relative humidity can decompose storage substances by photolysis, thermolysis, and hydrolysis process, respectively. The effect of physical factors may be the decomposition of pharmaceutical substances or their inappropriate action, including pharmacological effects. Polymers of natural origin are increasingly used in the pharmaceutical industry. With this in mind, we evaluated the effect of storage conditions on the stability of gum arabic (GA) and tragacanth (GT). The influence of higher temperature, UV irradiation, and relative humidity on GA and GT was tested. Thermogravimetry (TG, c-DTA), colorimetric analysis, UV-Vis spectrophotometry, and optical microscopy were used as research methods. The TGA and c-DTA examination indicated that decomposition of GA starts at a higher temperature compared to GT. This indicate that gum arabic is more resistant to higher temperatures compared to tragacanth. However, the conducted analysis showed that gum arabic is more sensitive to the tested storage conditions. Among the tested physical conditions, both polymers were most sensitive to conditions of increased relative humidity in the environment.

摘要

储存条件的选择应确保不影响活性药物物质（API）和药剂学中使用的赋形剂的作用和稳定性。紫外线辐射、温度升高和相对湿度会分别通过光解、热解和水解过程分解储存物质。物理因素的影响可能是药物物质的分解或其不当作用，包括药理作用。天然来源的聚合物在制药行业中的应用越来越多。考虑到这一点，我们评估了储存条件对阿拉伯胶（GA）和刺槐豆胶（GT）稳定性的影响。测试了较高温度、紫外线辐射和相对湿度对 GA 和 GT 的影响。热重分析（TG、c-DTA）、比色分析、紫外可见分光光度法和光学显微镜被用作研究方法。TGA 和 c-DTA 检查表明，与 GT 相比，GA 的分解在较高温度下开始。这表明与刺槐豆胶相比，阿拉伯胶对较高温度更具抵抗力。然而，进行的分析表明，阿拉伯胶对测试的储存条件更敏感。在测试的物理条件中，两种聚合物对环境中相对湿度增加的条件最敏感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/36a6d21b85a4/molecules-27-01510-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/0d0a6e534c1b/molecules-27-01510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/8148c3a9daa3/molecules-27-01510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/d635efc74945/molecules-27-01510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/6168da1030b0/molecules-27-01510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/c21b8faf93a9/molecules-27-01510-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/36a6d21b85a4/molecules-27-01510-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/0d0a6e534c1b/molecules-27-01510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/8148c3a9daa3/molecules-27-01510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/d635efc74945/molecules-27-01510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/6168da1030b0/molecules-27-01510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/c21b8faf93a9/molecules-27-01510-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66cb/8911758/36a6d21b85a4/molecules-27-01510-g006.jpg

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