Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, 00168 Rome, Italy.
Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Nutrients. 2024 Jul 2;16(13):2120. doi: 10.3390/nu16132120.
Current evidence suggests a beneficial role of herbal products in free radical-induced diseases. (Burk.) F. H. Chen has long occupied a leading position in traditional Chinese medicine because of the ergogenic, nootropic, and antistress activities, although these properties are also acknowledged in the Western world. The goal of this paper is to review the pharmacological and toxicological properties of and discuss its potential therapeutic effect. A literature search was carried out on Pubmed, Scopus, and the Cochrane Central Register of Controlled Trials databases. The following search terms were used: "notoginseng", "gut microbiota", "immune system", "inflammation", "cardiovascular system", "central nervous system", "metabolism", "cancer", and "toxicology". Only peer-reviewed articles written in English, with the full text available, have been included. Preclinical evidence has unraveled the pharmacological effects in immune-inflammatory, cardiovascular, central nervous system, metabolic, and neoplastic diseases by acting on several molecular targets. However, few clinical studies have confirmed the therapeutic properties of , mainly as an adjuvant in the conventional treatment of cardiovascular disorders. Further clinical studies, which both confirm the efficacy of in free radical-related diseases and delve into its toxicological aspects, are mandatory to broaden its therapeutic potential.
目前的证据表明，草药产品在自由基诱导的疾病中具有有益的作用。（Burk.）F. H. Chen 由于其具有的增强体力、益智和抗应激作用，在中药中一直占据着领先地位，尽管这些特性在西方世界也得到了认可。本文的目的是综述 的药理学和毒理学特性，并讨论其潜在的治疗效果。在 Pubmed、Scopus 和 Cochrane 中央对照试验登记处数据库上进行了文献检索。使用了以下搜索词：“三七”、“肠道微生物群”、“免疫系统”、“炎症”、“心血管系统”、“中枢神经系统”、“代谢”、“癌症”和“毒理学”。仅纳入了同行评议的、全文可用的、用英文撰写的文章。临床前证据表明， 通过作用于几个分子靶点，在免疫炎症、心血管、中枢神经系统、代谢和肿瘤疾病中发挥了 的药理作用。然而，很少有临床研究证实 的治疗特性，主要是作为心血管疾病常规治疗的辅助药物。需要进一步的临床研究来确认 在自由基相关疾病中的疗效，并深入研究其毒理学方面，以扩大其治疗潜力。
