Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.
Oniris, Department of Clinical Sciences, Nantes-Atlantic College of Veterinary Medicine and Food Sciences, University of Nantes, 101 Route de Gachet, 44300 Nantes, France.
Cells. 2022 Mar 5;11(5):901. doi: 10.3390/cells11050901.
Inflammatory bowel diseases (IBDs) have emerged as a public health problem worldwide with a limited number of efficient therapeutic options despite advances in medical therapy. Although changes in the gut microbiota composition are recognized as key drivers of dysregulated intestinal immunity, alterations in bile acids (BAs) have been shown to influence gut homeostasis and contribute to the pathogenesis of the disease. In this review, we explore the interactions involving BAs and gut microbiota in IBDs, and discuss how the gut microbiota-BA-host axis may influence digestive inflammation.
炎症性肠病（IBD）已成为全球性的公共卫生问题，尽管医学治疗取得了进展，但仍缺乏有效的治疗选择。尽管肠道微生物群落组成的变化被认为是肠道免疫失调的关键驱动因素，但胆汁酸（BAs）的改变已被证明会影响肠道内稳态并促进疾病的发病机制。在这篇综述中，我们探讨了 IBD 中涉及 BAs 和肠道微生物群的相互作用，并讨论了肠道微生物群-BA-宿主轴如何影响消化炎症。
