Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2022 Feb 22;23(5):2401. doi: 10.3390/ijms23052401.
For decades, scientists have been doing a lot of research and exploration to find effective long-term analgesic and/or disease-modifying treatments. Microneedles (MNs) are a simple, effective, and painless transdermal drug delivery technology that has emerged in recent years, and exhibits great promise for realizing intelligent drug delivery. With the development of materials science and fabrication technology, the MN transdermal drug delivery technology has been applied and popularized in more and more fields, including chronic illnesses such as arthritis or diabetes, cancer, dermatocosmetology, family planning, and epidemic disease prevention, and has made fruitful achievements. This paper mainly reviews the latest research status of MNs and their fabrication methodology, and summarizes the application of MNs in the treatment of various diseases, as well as the potential to use nanotechnology to develop more intelligent MNs-based drug delivery systems.
几十年来，科学家们一直在进行大量的研究和探索，以寻找有效的长期镇痛和/或疾病修正治疗方法。微针（MNs）是近年来出现的一种简单、有效、无痛的经皮药物输送技术，在实现智能药物输送方面具有很大的应用前景。随着材料科学和制造技术的发展，MN 经皮药物输送技术已经在越来越多的领域得到应用和普及，包括关节炎或糖尿病等慢性病、癌症、皮肤美容学、计划生育和传染病预防等领域，并取得了丰硕的成果。本文主要综述了 MNs 的最新研究现状及其制造方法，并总结了 MNs 在各种疾病治疗中的应用，以及利用纳米技术开发更智能的基于 MNs 的药物输送系统的潜力。
