School of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea.
Department of Mechanical Engineering, University of Engineering and Technology, Mardan, Khyber Pakhtunkhwa, 23200, Pakistan.
Sci Rep. 2024 Aug 20;14(1):19228. doi: 10.1038/s41598-024-70393-8.
For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug loading and analytics sampling and improve drug penetration while maintaining painless administration, patch-type microneedle arrays were designed and fabricated using polymer casting from a conical cavity mold. Microcavities were formed on a carbon plate via micromechanical machining. A porous polymer layer was coated on a microneedle patch (MNP). The pores of the porous polymer layer provided space and channels for drug delivery. A pH-sensitive polymer layer was employed to cap the porous polymer layer, which prevented drug leakage during storage and provided a stimulus drug release in response to body pH conditions. The drug can be delivered through holes connected to both sides of the patch. The drug release of the MNP was investigated in vitro and in vivo and showed conceptual proof that these MNs have the potential to enhance treatment protocols for various diseases with the flexibility of coating and therapeutic materials and offer significant scope for further variations and advancement.
为了成功治疗疾病，必须向体内提供足够的治疗药物。由于各种问题，包括用于药物加载和分析采样的较小面积，微针在治疗药物输送和分析采样中的应用受到限制。为了在保持无痛给药的同时实现足够的药物加载和分析采样以及提高药物渗透，使用锥形腔模具的聚合物浇铸设计并制造了贴片式微针阵列。通过微机械加工在碳板上形成微腔。在微针贴片（MNP）上涂覆多孔聚合物层。多孔聚合物层的孔为药物输送提供了空间和通道。使用 pH 敏感聚合物层覆盖多孔聚合物层，该层在储存过程中防止药物泄漏，并在响应身体 pH 条件时提供刺激药物释放。药物可以通过连接贴片两侧的孔输送。对 MNP 的药物释放进行了体外和体内研究，概念验证表明，这些 MN 具有通过涂覆和治疗材料的灵活性增强各种疾病治疗方案的潜力，并为进一步的变化和发展提供了广阔的空间。
