Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
CEINGE-Biotecnologie Avanzate s.c.ar.l., 80145 Naples, Italy.
Int J Mol Sci. 2022 Feb 22;23(5):2414. doi: 10.3390/ijms23052414.
Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic.
在这场史无前例的全球 COVID-19 大流行期间，基于组学的技术得到了广泛应用，使科学界能够大规模开展研究，以了解 SARS-CoV-2 感染的病理生物学及其在人类细胞中的复制。组学技术的应用已经涉及到各个应用层面，从检测突变、诊断或监测方法、药物靶点发现和疫苗生成，到感染和传播 SARS-CoV-2 的病理生理过程和生化机制的基本定义。因此，COVIDomics 一词旨在包括应用于当前 COVID-19 研究的组学规模调查所提供的这些努力。本综述总结了应用 COVIDomics 技术获得的各种知识，主要集中在蛋白质组学和代谢组学研究方面，以捕捉 COVID-19 疾病中失调的蛋白质、代谢物和途径的共同特征。探索多组学视角和并发数据集成可能为抗击 COVID-19 大流行提供新的合适的治疗解决方案。
