König W, Tesch H, Frickhofen N
Eur J Immunol. 1978 Jun;8(6):434-7. doi: 10.1002/eji.1830080612.
This study describes the generation and release of an eosinophil chemotactic factor from human polymorphonuclear neutrophils, rat basophilic leukemia cells, and from a lymphocyte monocyte basophil suspension by arachidonic acid (AA). The eosinophil chemotactic factor (ECF) is highly specific for eosinophils and resembles the ECF activity obtained from human polymorphonuclear neutrophils after stimulation with the Ca ionophore or during phagocytosis. In this regard, AA-induced ECF represents a biological activity distinct from oxidized AA and its conversion products. AA may therefore have a dual function: it represents an important mechanism of cell activation; as AA is converted into prostaglandins, it appears likely that they exert a modulatory and a suppressive role on biological functions, such as chemotaxis and phagocytosis.
本研究描述了花生四烯酸（AA）从人多形核中性粒细胞、大鼠嗜碱性白血病细胞以及淋巴细胞 - 单核细胞 - 嗜碱性粒细胞悬液中产生并释放嗜酸性粒细胞趋化因子的过程。嗜酸性粒细胞趋化因子（ECF）对嗜酸性粒细胞具有高度特异性，类似于用钙离子载体刺激人多形核中性粒细胞后或在吞噬过程中获得的ECF活性。在这方面，AA诱导的ECF代表一种不同于氧化型AA及其转化产物的生物活性。因此，AA可能具有双重功能：它代表细胞活化的重要机制；随着AA转化为前列腺素，它们似乎对趋化性和吞噬作用等生物学功能发挥调节和抑制作用。
