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1
Generation of slow-reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes.内毒素和脂质A诱导人多形核粒细胞产生慢反应物质（白三烯）
Immunology. 1984 Oct;53(2):299-305.
2
Generation of leukotrienes and lipoxygenase factors from human polymorphonuclear granulocytes during bacterial phagocytosis and interaction with bacterial exotoxins.细菌吞噬过程中以及与细菌外毒素相互作用时，人多形核粒细胞中白三烯和脂氧合酶因子的生成。
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1983 Jul;254(4):500-14.
3
Modulation of granulocyte functions by bacterial exotoxin and endotoxins.细菌外毒素和内毒素对粒细胞功能的调节
Immunology. 1987 Nov;62(3):363-71.
4
Are the leukotrienes involved in the bronchial asthma?白三烯与支气管哮喘有关吗？
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5
A case for an endotoxic conformation.关于内毒素构象的一个实例。
Prog Clin Biol Res. 1994;388:17-30.
6
Measurement of leukotrienes.白三烯的测定
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7
Effect of bacterial endotoxin on lipoxygenase and cyclo-oxygenase metabolites by rat neutrophils and correlation with cellular functional parameters.细菌内毒素对大鼠中性粒细胞脂氧合酶和环氧化酶代谢产物的影响及其与细胞功能参数的相关性
Res Exp Med (Berl). 1988;188(1):9-17. doi: 10.1007/BF01852089.
8
Generation of leukotrienes from human granulocytes by alveolysin from Bacillus alvei.来自蜂房芽孢杆菌的肺泡溶素诱导人粒细胞生成白三烯。
Infect Immun. 1984 Apr;44(1):188-93. doi: 10.1128/iai.44.1.188-193.1984.
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Influence of bacterial endotoxins on neutrophilic leukocytes: lack of a correlation between in vivo and in vitro responses.细菌内毒素对嗜中性白细胞的影响：体内和体外反应之间缺乏相关性。
Prog Clin Biol Res. 1981;62:157-72.
10
[The eosinophil--the human blood cell superaffined to endotoxin].[嗜酸性粒细胞——与内毒素高度亲和的人类血细胞]
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引用本文的文献

1
Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation.
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2
Modulation of granulocyte functions by bacterial exotoxin and endotoxins.细菌外毒素和内毒素对粒细胞功能的调节
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Role of cloned virulence factors (mannose-resistant haemagglutination, mannose-resistant adhesions) from uropathogenic Escherichia coli strains in the release of inflammatory mediators from neutrophils and mast cells.尿路致病性大肠杆菌菌株的克隆毒力因子（抗甘露糖血凝素、抗甘露糖黏附素）在中性粒细胞和肥大细胞释放炎症介质中的作用。
Immunology. 1989 Jul;67(3):401-7.
4
Recombinant interferon-gamma primes alveolar macrophages cultured in vitro for the release of leukotriene B4 in response to IgG stimulation.重组干扰素-γ使体外培养的肺泡巨噬细胞致敏，使其在受到IgG刺激时释放白三烯B4。
J Clin Invest. 1989 May;83(5):1691-700. doi: 10.1172/JCI114069.
5
Inhibition of polymorphonuclear leucocyte functions in vivo by Yersinia enterocolitica lipopolysaccharide.小肠结肠炎耶尔森菌脂多糖对体内多形核白细胞功能的抑制作用。
Ann Rheum Dis. 1989 Jan;48(1):42-7. doi: 10.1136/ard.48.1.42.
6
Comparison of four hemolysin-producing organisms (Escherichia coli, Serratia marcescens, Aeromonas hydrophila, and Listeria monocytogenes) for release of inflammatory mediators from various cells.比较四种产生溶血素的生物体（大肠杆菌、粘质沙雷氏菌、嗜水气单胞菌和单核细胞增生李斯特菌）从各种细胞中释放炎症介质的情况。
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7
Role of cell-bound hemolysin as a pathogenicity factor for Serratia infections.细胞结合溶血素作为沙雷氏菌感染致病因素的作用。
Infect Immun. 1987 Nov;55(11):2554-61. doi: 10.1128/iai.55.11.2554-2561.1987.
8
Induction of inflammatory mediators from human polymorphonuclear granulocytes and rat mast cells by haemolysin-positive and -negative E. coli strains with different adhesins.具有不同黏附素的溶血素阳性和阴性大肠杆菌菌株对人多形核粒细胞和大鼠肥大细胞炎症介质的诱导作用。
Immunology. 1986 Dec;59(4):541-8.
9
Role of Escherichia coli alpha-hemolysin and bacterial adherence in infection: requirement for release of inflammatory mediators from granulocytes and mast cells.大肠杆菌α-溶血素和细菌黏附在感染中的作用：从粒细胞和肥大细胞释放炎症介质的必要条件。
Infect Immun. 1986 Dec;54(3):886-92. doi: 10.1128/iai.54.3.886-892.1986.
10
Bacterial adherence and hemolysin production from Escherichia coli induces histamine and leukotriene release from various cells.大肠杆菌产生的细菌黏附和溶血素可诱导多种细胞释放组胺和白三烯。
Infect Immun. 1985 Oct;50(1):271-8. doi: 10.1128/iai.50.1.271-278.1985.

本文引用的文献

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Leukotriene antagonists prevent endotoxin lethality.
Naturwissenschaften. 1982 Dec;69(12):594-5. doi: 10.1007/BF00396357.
2
Evidence for pulmonary release of 5-hydroxyeicosatetraenoic acid (5-hete) during endotoxemia in unanesthetized sheep.未麻醉绵羊内毒素血症期间肺释放5-羟基二十碳四烯酸（5-HETE）的证据。
Prostaglandins. 1982 Apr;23(4):459-68. doi: 10.1016/0090-6980(82)90109-5.
3
Granulocyte activation by endotoxin. I. Correlation between adherence and other granulocyte functions, and role of endotoxin structure on biologic activity.内毒素诱导的粒细胞激活。I. 黏附与其他粒细胞功能之间的相关性，以及内毒素结构对生物活性的作用。
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4
Release of leukotriene C4 from human polymorphonuclear leucocytes as determined by radioimmunoassay.通过放射免疫测定法测定人多形核白细胞中白三烯C4的释放。
FEBS Lett. 1982 Sep 6;146(1):111-4. doi: 10.1016/0014-5793(82)80715-1.
5
Effects of cyclooxygenase inhibitors on pulmonary vascular responses to endotoxin in unanesthetized sheep.环氧化酶抑制剂对未麻醉绵羊肺血管对内毒素反应的影响。
Prostaglandins Leukot Med. 1982 May;8(5):489-502.
6
Leukotriene C4: isolation from human polymorphonuclear leukocytes.白三烯C4：从人多形核白细胞中分离得到。
FEBS Lett. 1980 Dec 15;122(1):87-90. doi: 10.1016/0014-5793(80)80408-x.
7
Thromboxane A2 mediates augmented polymorphonuclear leukocyte adhesiveness.血栓素A2介导多形核白细胞黏附性增强。
J Clin Invest. 1980 Sep;66(3):406-14. doi: 10.1172/JCI109870.
8
Enzymatic deacylation of the lipid A moiety of Salmonella typhimurium lipopolysaccharides by human neutrophils.人中性粒细胞对鼠伤寒沙门氏菌脂多糖脂质A部分的酶促脱酰作用。
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6671-5. doi: 10.1073/pnas.80.21.6671.
9
Generation of leukotrienes and lipoxygenase factors from human polymorphonuclear granulocytes during bacterial phagocytosis and interaction with bacterial exotoxins.细菌吞噬过程中以及与细菌外毒素相互作用时，人多形核粒细胞中白三烯和脂氧合酶因子的生成。
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1983 Jul;254(4):500-14.
10
Generation of leukotrienes from human granulocytes by alveolysin from Bacillus alvei.来自蜂房芽孢杆菌的肺泡溶素诱导人粒细胞生成白三烯。
Infect Immun. 1984 Apr;44(1):188-93. doi: 10.1128/iai.44.1.188-193.1984.

内毒素和脂质A诱导人多形核粒细胞产生慢反应物质（白三烯）

Generation of slow-reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes.

作者信息

Bremm K D, König W, Spur B, Crea A, Galanos C

出版信息

Immunology. 1984 Oct;53(2):299-305.

PMID:6490085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454833/
Abstract

Leukotrienes were released from human polymorphonuclear granulocytes on incubation with endotoxins and lipid A. The analysis was performed by their smooth muscle contracting properties, reversed phase high-pressure liquid chromatography and radioimmunoassay for leukotrienes C4 and D4. The active component of the lipopolysaccharides seems to be the lipid A portion.

摘要

人多形核粒细胞与内毒素和脂多糖A一起孵育时会释放白三烯。通过其平滑肌收缩特性、反相高效液相色谱法以及对白三烯C4和D4的放射免疫测定法进行分析。脂多糖的活性成分似乎是脂多糖A部分。