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内毒素和脂质A诱导人多形核粒细胞产生慢反应物质(白三烯)

Generation of slow-reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes.

作者信息

Bremm K D, König W, Spur B, Crea A, Galanos C

出版信息

Immunology. 1984 Oct;53(2):299-305.

Abstract

Leukotrienes were released from human polymorphonuclear granulocytes on incubation with endotoxins and lipid A. The analysis was performed by their smooth muscle contracting properties, reversed phase high-pressure liquid chromatography and radioimmunoassay for leukotrienes C4 and D4. The active component of the lipopolysaccharides seems to be the lipid A portion.

摘要

人多形核粒细胞与内毒素和脂多糖A一起孵育时会释放白三烯。通过其平滑肌收缩特性、反相高效液相色谱法以及对白三烯C4和D4的放射免疫测定法进行分析。脂多糖的活性成分似乎是脂多糖A部分。

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