Mihara K, Isoda M
Br J Dermatol. 1986 Aug;115(2):187-92. doi: 10.1111/j.1365-2133.1986.tb05716.x.
The lysozyme activity in tissue samples from patients with lupus miliaris disseminatus faciei (LMDF), sarcoidosis and foreign body granuloma was investigated using the immunoperoxidase technique. The majority of epithelioid cells and giant cells in LMDF and sarcoidosis showed strong lysozyme staining in their cytoplasm. However, most macrophages and giant cells in foreign body granulomas, including granulomatous reactions to epidermal cysts and other foreign materials, stained weakly for lysozyme or were negative. These results suggest that LMDF is different from the foreign body reaction to inert substances, and may be induced by an immunological mechanism associated with cell-mediated immunity.
采用免疫过氧化物酶技术研究了播散性粟粒性狼疮（LMDF）、结节病和异物肉芽肿患者组织样本中的溶菌酶活性。LMDF和结节病中的大多数上皮样细胞和巨细胞在其细胞质中显示出强烈的溶菌酶染色。然而，异物肉芽肿中的大多数巨噬细胞和巨细胞，包括对表皮囊肿和其他异物的肉芽肿反应，溶菌酶染色较弱或呈阴性。这些结果表明，LMDF不同于对惰性物质的异物反应，可能是由与细胞介导免疫相关的免疫机制诱导的。
