Zheng Zelong, Wang Qi, Sun Shujie, Luo Jinbiao
The Department of Neurosurgery, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Institute of Eco-Environmental and Soil Science, Guangdong Academy of Sciences, Guangzhou, China.
Front Neurol. 2022 Feb 22;13:755501. doi: 10.3389/fneur.2022.755501. eCollection 2022.
Spontaneous intracerebral hemorrhage (ICH), especially related to intraventricular hemorrhage (IVH), is the most devastating type of stroke and is associated with high mortality and morbidity. Optimal management of ICH remains one of the most controversial areas of neurosurgery and no effective treatment exists for ICH. Studies comparing conventional surgical interventions with optimal medical management failed to show significant benefit. Recent exploration of minimally invasive surgery for ICH and IVH including catheter- and mechanical-based approaches has shown great promise. Early phase clinical trials have confirmed the safety and preliminary treatment effect of minimally invasive surgery for ICH and IVH. Pending efficacy data from phase III trials dealing with diverse minimally invasive techniques are likely to shape the treatment of ICH.
自发性脑出血(ICH),尤其是与脑室内出血(IVH)相关的脑出血,是最具破坏性的中风类型,且与高死亡率和高发病率相关。ICH的最佳治疗方案仍然是神经外科最具争议的领域之一,目前尚无针对ICH的有效治疗方法。比较传统手术干预与最佳药物治疗的研究未能显示出显著益处。最近对ICH和IVH的微创手术的探索,包括基于导管和机械的方法,已显示出巨大的前景。早期临床试验已经证实了ICH和IVH微创手术的安全性和初步治疗效果。处理各种微创技术的III期试验的疗效数据待定,这可能会影响ICH的治疗。