Cancer Research Center, Xiamen University School of Medicine, Xiamen, China.
Department of General Surgery, The First Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Front Immunol. 2022 Feb 22;13:788375. doi: 10.3389/fimmu.2022.788375. eCollection 2022.
Previous research found that LIM domain kinase 2 (LIMK2) expression correlated with a poor prognosis in many cancers. However, its role in lung squamous cell carcinoma (LUSC) has not yet been clarified. Our study aimed to clarify the role of LIMK2 in LUSC prognosis prediction and explore the relationship between LIMK2 and immune infiltration in LUSC. In this study, we first analyzed the expression level and prognostic value of LIMK2 across cancers. Subsequently, we explored the association of LIMK2 expression with immune infiltrating cells and immune checkpoints. our study found that LIMK2 was highly expressed and positively associated with the overall survival of LUSC. Moreover, our study further indicated that LIMK2 expression was significantly negatively correlated with immune cell infiltration and immune checkpoints in LUSC. Finally, we confirmed upstream regulatory noncoding RNAs (ncRNAs) of LIMK2, and the PVT1 and DHRS4-AS1/miR-423-5p/LIMK2 regulatory axes were successfully constructed in LUSC. Put together, LIMK2 is a novel prognostic biomarker and correlates with tumor immune cell infiltration in LUSC, and the expression of LIMK2 is regulated by the PVT1 and DHRS4-AS1/miR-423-5p axes.
先前的研究发现 LIM 结构域激酶 2（LIMK2）在许多癌症中的表达与不良预后相关。然而，其在肺鳞状细胞癌（LUSC）中的作用尚未阐明。本研究旨在阐明 LIMK2 在 LUSC 预后预测中的作用，并探讨 LIMK2 与 LUSC 免疫浸润之间的关系。在本研究中，我们首先分析了 LIMK2 在各种癌症中的表达水平和预后价值。随后，我们探讨了 LIMK2 表达与免疫浸润细胞和免疫检查点之间的关联。我们的研究发现 LIMK2 在 LUSC 中高表达，并与总生存期呈正相关。此外，我们的研究还表明，LIMK2 表达与 LUSC 中的免疫细胞浸润和免疫检查点呈显著负相关。最后，我们验证了 LIMK2 的上游调控非编码 RNA（ncRNA），并成功构建了 LUSC 中的 PVT1 和 DHRS4-AS1/miR-423-5p/LIMK2 调控轴。综上所述，LIMK2 是 LUSC 中的一种新型预后生物标志物，与肿瘤免疫细胞浸润相关，LIMK2 的表达受 PVT1 和 DHRS4-AS1/miR-423-5p 轴的调控。
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