Al-Mughales Jamil, Wali Siraj Omar, Manzar Md Dilshad, Alhejaili Faris, Gozal David
King Abdulaziz University Hospital, Diagnostic Immunology Division, Department of Clinical Laboratory Medicine - Jeddah - Jeddah - Saudi Arabia.
Faculty of Medicine, King Abdulaziz University, Department of Medical Microbiology and Parasitology Immunology Division - Jeddah - Jeddah - Saudi Arabia.
Sleep Sci. 2022 Jan-Mar;15(Spec 1):20-27. doi: 10.5935/1984-0063.20200117.
To evaluate the association of obstructive sleep apnea (OSA) with high-sensitivity C-reactive protein (CRP) and fibrinogen levels and to assess the effect of short-term therapy using continuous positive airway pressure (CPAP).
A prospective, open-label, controlled trial was conducted among clinically referred patients at risk for OSA undergoing diagnostic polysomnography (PSG). After PSG, the patients were divided into 3 groups: OSA treatment group (TG) (n=21), untreated OSA group (UOG) (n=19), and non-OSA healthy control group (HCG) (n=24). CRP and fibrinogen levels were measured at baseline and one month after treatment. Repeated-measures (RM) ANOVA and ANCOVA were used to compare changes in CRP and fibrinogen levels among the three groups by analyzing between-subject and within-subject effects as functions of time and adjusting for significant covariates.
At baseline, OSA subjects had significantly higher CRP [t(52.37)=-2.46, p=0.02)] and fibrinogen levels [t(57)=-2.00, p=0.05)] than HCG subjects. No significant differences in CRP levels [(F(2,58)=2.29, p=0.11)] or fibrinogen levels [(F(2, 58)=1.28, p=0.29)] emerged between TG and HCG subjects after adjusting for the pretest levels.
CPAP therapy for one month does not affect CRP and fibrinogen levels among moderate-to-severe OSA patients. However, OSA is associated with elevated levels of these inflammatory biomarkers.
评估阻塞性睡眠呼吸暂停（OSA）与高敏C反应蛋白（CRP）及纤维蛋白原水平之间的关联，并评估持续气道正压通气（CPAP）短期治疗的效果。
对临床上被转诊的有OSA风险且正在接受诊断性多导睡眠图（PSG）检查的患者进行了一项前瞻性、开放标签、对照试验。PSG检查后，患者被分为3组：OSA治疗组（TG）（n = 21）、未经治疗的OSA组（UOG）（n = 19）和非OSA健康对照组（HCG）（n = 24）。在基线和治疗后1个月测量CRP和纤维蛋白原水平。采用重复测量（RM）方差分析和协方差分析，通过分析组间和组内效应随时间的变化并对显著协变量进行校正，比较三组之间CRP和纤维蛋白原水平的变化。
在基线时，OSA患者的CRP水平[t(52.37)= -2.46，p = 0.02]和纤维蛋白原水平[t(57)= -2.00，p = 0.05]显著高于HCG组患者。在对预测试水平进行校正后，TG组和HCG组患者之间的CRP水平[F(2,58)= 2.29，p = 0.11]或纤维蛋白原水平[F(2, 58)= 1.28，p = 0.29]没有显著差异。
对中重度OSA患者进行1个月的CPAP治疗不会影响CRP和纤维蛋白原水平。然而，OSA与这些炎症生物标志物水平升高有关。
