内源性大麻素系统，肥胖症和代谢性疾病药物治疗中一个未被充分利用且前景广阔的领域。
The Endocannabinoid System, an Underexploited and Promising Niche for the Pharmacological Treatment of Obesity and Metabolic Diseases.
作者信息
Gómez-Ambrosi Javier
机构信息
Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
出版信息
Nutrients. 2022 Jan 18;14(3):421. doi: 10.3390/nu14030421.
Abstract
Obesity represents the most prevalent metabolic disease in the world at present, posing an important public health challenge [...].
摘要
肥胖是目前全球最普遍的代谢性疾病，构成了一项重大的公共卫生挑战[……]
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本文引用的文献
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Anti-obesity drug discovery: advances and challenges.抗肥胖药物的发现：进展与挑战。
Nat Rev Drug Discov. 2022 Mar;21(3):201-223. doi: 10.1038/s41573-021-00337-8. Epub 2021 Nov 23.
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Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity.内源性大麻素与摄食和肥胖的肠道-大脑控制。
Nutrients. 2021 Apr 7;13(4):1214. doi: 10.3390/nu13041214.
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Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass.内源性大麻素受体 1 和交感神经系统介导胃旁路手术的有益代谢效应。
Cell Rep. 2020 Oct 27;33(4):108270. doi: 10.1016/j.celrep.2020.108270.
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Nutrients. 2020 Sep 20;12(9):2874. doi: 10.3390/nu12092874.
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Obesity Affects the Microbiota-Gut-Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators.肥胖影响微生物群-肠道-大脑轴及其受内源性大麻素和相关介质的调节。
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