University of California, Riverside School of Medicine, Riverside, CA, USA.
College of Medicine, California Northstate University, Elk Grove, CA, USA.
J Altern Complement Med. 2021 Apr;27(4):294-311. doi: 10.1089/acm.2020.0292. Epub 2020 Dec 18.
Vitiligo is an autoimmune skin condition that affects people globally anywhere, from <0.1% to more than 8% of individuals. The disease destroys skin melanocytes, resulting in a patchy depigmentation of the skin. About 50% of all patients develop the disease before their 20s. We systematically searched the literature and reviewed the evidence for the use of nutritional supplements and diet in the management of vitiligo. Embase and Medline were searched for diet, herbal, and nutrition-based clinical studies. Additional filters were applied that looked for controlled trial or randomized controlled trial and article or article in press or letter and English and clinical study. We selected clinical studies in humans that showed how diet or natural supplements can improve the symptoms of vitiligo in all of our searches. There were 62 manuscripts that resulted from the PubMed search and 259 from the Embase search. A final of 26 studies were reviewed, and other supplemental case and case-control studies were used to introduce diet components that may influence either exacerbation or amelioration of vitiligo. Possible mechanisms of action are introduced for natural and supplemental interventions. Some of the supplements reviewed include , oral , alpha lipoic acid, vitamins B12, D, and E, folic acid, phenylalanine, canthaxanthin, oil, and other combined herbal bio-actives. Overall, the growing evidence is promising, but more studies are needed in this area to further explore the impact that supplements and diet can have on vitiligo management. The most promising therapies included oral phenylalanine as adjuvant therapy with UVA therapy, oral as monotherapy, both of which can be used with other traditional therapies, and oral with phototherapy or photochemotherapy.
白癜风是一种影响全球人群的自身免疫性皮肤病，发病率在 0.1%至 8%以上不等。该疾病会破坏皮肤中的黑色素细胞，导致皮肤出现斑驳的色素脱失。大约 50%的患者在 20 岁之前发病。
我们系统地检索了文献，并综述了营养补充剂和饮食在白癜风管理中的应用证据。我们在 Embase 和 Medline 上检索了基于饮食、草药和营养的临床研究。此外，还应用了其他筛选条件，包括对照试验或随机对照试验、文章或即将发表的文章或信函，以及英文和临床研究。我们选择了显示饮食或天然补充剂如何改善白癜风所有症状的人体临床研究。
从 PubMed 搜索中得到了 62 篇论文，从 Embase 搜索中得到了 259 篇论文。最终有 26 项研究被审查，其他补充的病例和病例对照研究被用来介绍可能影响白癜风恶化或改善的饮食成分。介绍了天然和补充干预措施的可能作用机制。
审查的一些补充剂包括口服α-硫辛酸、维生素 B12、D 和 E、叶酸、苯丙氨酸、叶黄素、鱼肝油和其他组合的草药生物活性物质。总的来说，越来越多的证据是有希望的，但在这一领域需要更多的研究来进一步探讨补充剂和饮食对白癜风管理的影响。最有前途的疗法包括口服苯丙氨酸作为 UVA 治疗的辅助疗法，口服作为单一疗法，两者都可以与其他传统疗法一起使用，以及口服与光疗或光化学疗法一起使用。
