Attia Marwa M, Yehia Nahed, Mohamed Soliman Mohamed, Shukry Mustafa, El-Saadony Mohamed T, Salem Heba M
Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt.
Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center, Giza 12618, Egypt.
Saudi J Biol Sci. 2022 Mar;29(3):1644-1652. doi: 10.1016/j.sjbs.2021.10.067. Epub 2021 Oct 29.
This study aimed to evaluate the efficacy of chitosan-silver nanocomposites in the treatment of experimentally infested pigeons with () with evaluation of different immunological parameters before and after treatment. Therefore, fourteen birds were divided into 2 groups; group1(infested group including 12 birds) which subdivided into 6 sub-groups experimentally infested pigeons 2 pigeons each, and five group of them were treated with chitosan-silver nanocomposites and sub-group number 6 was treated with deltamethrin while, group 2 including two pigeons were kept as control negative ones. flies distributed under the wing and /or under the tail in infested group and these pigeons showed significantly lower RBCs and higher WBCs than that in non-infested pigeons. The cell mediated immune response against experimentally infested pigeons with was studied. infestation in pigeons have a negative impact on pigeon's blood parameters, increase TNF-α and IL-1β cytokines levels. This study cleared out the role of in the induction of a case of oxidative stress indicated by high level of nitric oxide and malondialdehyde (MDA) with low antioxidant capacity in shape of reduced zinc concentration in the sera of experimentally infested pigeon. Chitosan-silver nanocomposite has a promising effect in the elimination of infestation in pigeons.
本研究旨在评估壳聚糖-银纳米复合材料对实验性感染（此处原文括号内容缺失）鸽子的治疗效果，并在治疗前后评估不同的免疫参数。因此，将14只鸽子分为2组；第1组（感染组，包括12只鸽子）进一步细分为6个亚组，每个亚组有2只实验性感染的鸽子，其中5个亚组用壳聚糖-银纳米复合材料治疗，第6亚组用溴氰菊酯治疗，而第2组包括2只鸽子作为阴性对照。感染组的苍蝇分布在翅膀下方和/或尾巴下方，这些鸽子的红细胞数量明显低于未感染的鸽子，白细胞数量则高于未感染的鸽子。研究了针对实验性感染（此处原文括号内容缺失）鸽子的细胞介导免疫反应。鸽子感染（此处原文括号内容缺失）会对鸽子的血液参数产生负面影响，增加肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）细胞因子水平。本研究明确了（此处原文括号内容缺失）在诱导氧化应激中的作用，表现为实验性感染鸽子血清中一氧化氮和丙二醛（MDA）水平升高，而抗氧化能力降低，以锌浓度降低的形式体现。壳聚糖-银纳米复合材料在消除鸽子感染（此处原文括号内容缺失）方面具有良好的效果。
