Microbiology Department, Virgen de las Nieves University Hospital, Avda. Fuerzas Armadas, 2, 18014, Granada, Spain,
Mycopathologia. 2014 Feb;177(1-2):97-101. doi: 10.1007/s11046-013-9715-3. Epub 2013 Nov 1.
Mucormycosis is an uncommon opportunistic fungal infection caused by Zygomycetes. It usually affects immunocompromised, diabetic and trauma patients with infected wounds. We report a case of disseminated infection secondary to facial cutaneous mucormycosis caused by Saksenaea vasiformis in a diabetic patient who had a farming accident causing him severe head injury. The patient was treated with a combination of surgical debridement and antifungal therapy with liposomal amphotericin B, but he had a slow and fatal outcome. In cases of tissue necrosis following trauma involving wound contact with soil (i.e., potential fungal contamination), testing for the presence of Zygomycetes fungi such as S. vasiformis in both immunocompetent and immunocompromised patients is crucial. The reason is that this infection usually has a rapid progression and may be fatal if appropriate treatment is not administered.
毛霉病是一种由接合菌引起的罕见机会性真菌感染。它通常影响免疫功能低下、糖尿病和创伤患者，这些患者的感染伤口会导致发病。我们报告了一例由萨氏毛霉引起的面部皮肤毛霉病继发全身播散性感染的病例，该患者为糖尿病患者，因农业事故导致严重颅脑损伤。该患者接受了手术清创和两性霉素 B 脂质体抗真菌治疗，但病情进展缓慢，最终死亡。对于创伤后组织坏死的病例，特别是伤口与土壤接触（即存在潜在真菌感染）的情况下，无论是免疫功能正常还是免疫功能低下的患者，都需要检测是否存在接合菌真菌，如萨氏毛霉。这是因为这种感染通常进展迅速，如果不给予适当的治疗，可能会致命。
