Wu Meifang, Su Xiangdong, Wu Yichuang, Luo Yuanjing, Guo Ying, Xue Yongbo
School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, No. 66 Gongchang Road, Shenzhen, 518107, China.
Beilstein J Org Chem. 2022 Feb 16;18:200-207. doi: 10.3762/bjoc.18.23. eCollection 2022.
Champ. ex Benth., a traditional herbal medicine collected at the Lingnan region of China, was chemically investigated. A new biscoumarin glucoside, wikstronutin (), along with three known bis- and tricoumarin glucosides (-), two flavonoid glycosides (-), and eleven lignan glucosides (-) were isolated from the stems and roots of . The new structure including its absolute configuration was elucidated based on a combination of 1D and 2D NMR, UV, IR, HRESIMS spectroscopic data, as well as chemical transformation. Compounds - were first isolated from the plant species , while compounds -, , and were reported from the genus for the first time. All co-isolates were evaluated for their in vitro inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells. The antibacterial activity of the selected compounds was also tested. Our work enriches the structure diversity of the secondary metabolites from the genus
中国岭南地区采集的传统草药铁箍散（Champ. ex Benth.）进行了化学研究。从铁箍散的茎和根中分离出一种新的双香豆素糖苷——铁箍散苷（wikstronutin），以及三种已知的双香豆素和三香豆素糖苷、两种黄酮糖苷和十一种木脂素糖苷。基于一维和二维核磁共振、紫外、红外、高分辨电喷雾电离质谱光谱数据以及化学转化，阐明了新结构及其绝对构型。化合物首次从该植物物种中分离得到，而化合物首次从该属植物中报道。评估了所有共分离物对小鼠RAW264.7巨噬细胞中脂多糖（LPS）诱导的一氧化氮（NO）产生的体外抑制作用。还测试了所选化合物的抗菌活性。我们的工作丰富了该属植物次生代谢产物的结构多样性。
