Zhao Long-Fei, Zhang Jin-Ge, Qi Feng-Yu, Hou Wei-Yan, Li Yin-Rui, Shen Dan-Dan, Zhao Li-Juan, Qi Lin, Liu Hong-Min, Zheng Yi-Chao
Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Comput Struct Biotechnol J. 2022 Feb 26;20:1068-1076. doi: 10.1016/j.csbj.2022.02.023. eCollection 2022.
Sex differences are evident in the incidence and mortality of diverse cancers. With the development of personalized approaches in cancer treatment, the impact of sex differences has not been systematically incorporated into preclinical and clinical cancer research. The molecular mechanisms underlying sex differences in cancer have not been elucidated. Here, we developed the first database of Sex Differences in Cancer (SDC), a web-based public database that integrates resources from multiple databases, including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression Project (GTEx), UCSC Xena, Broad Institute Cancer Cell Line Encyclopedia (CCLE), Genomics of Drug Sensitivity in Cancer (GDSC). SDC contains 27 types of cancers, 6 types of molecular data, more than 10,000 donors, 977 cancer cell lines were used to analyze sex differences among cancers. It provides five main modules: Survival and phenotype, Molecular differences, Signatures and pathways, Therapy response, Download. Users can download the all the visualized results and raw data after analysis. Collectively, SDC is the first integrated database to analyze sex differences in cancer on the web server, which will strengthen our understanding of the role of sex in cancers. It is implemented in Shiny-server and freely available for public use at http://sdc.anticancer.xyz.
性别差异在多种癌症的发病率和死亡率中很明显。随着癌症治疗中个性化方法的发展，性别差异的影响尚未系统地纳入临床前和临床癌症研究。癌症中性别差异的分子机制尚未阐明。在此，我们开发了首个癌症性别差异数据库（SDC），这是一个基于网络的公共数据库，整合了来自多个数据库的资源，包括癌症基因组图谱（TCGA）、基因型-组织表达项目（GTEx）、加州大学圣克鲁兹分校Xena、布罗德研究所癌症细胞系百科全书（CCLE）、癌症药物敏感性基因组学（GDSC）。SDC包含27种癌症类型、6种分子数据、10000多名捐赠者，使用977个癌细胞系来分析癌症之间的性别差异。它提供五个主要模块：生存与表型、分子差异、特征与通路、治疗反应、下载。用户在分析后可以下载所有可视化结果和原始数据。总体而言，SDC是首个在网络服务器上分析癌症性别差异的综合数据库，这将加强我们对性别在癌症中作用的理解。它在Shiny-server中实现，可在http://sdc.anticancer.xyz上免费供公众使用。
