State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, 570228, P. R. China.
Small. 2022 Apr;18(16):e2107401. doi: 10.1002/smll.202107401. Epub 2022 Mar 14.
The generation of undesired biofouling in medical and engineering applications results in a reduction in function and durability. Copying functionalities of natural enzymes to combat biofouling by artificial nanomaterials is highly attractive but still challenged by the inferior catalytic activity and specificity principally because of low densities of active sites. Here, an innovate strategy is demonstrated to stabilize high-density ultrasmall ceria clusters on zirconia for biofouling prevention. Benefiting from the unique structure, CeO @ZrO nanozyme can significantly enhance the haloperoxidase-mimicking activity in catalyzing the oxidation of bromide with H O into biocidal hypobromous acid as a result of abundant defects and surface strong acidity sites, inducing impressive antibacterial and antibiofouling capacity compared with that of pristine CeO . This work is expected to open a new avenue for the rational design of cluster catalysts for various targeting catalytic applications.
在医学和工程应用中，不良生物污垢的产生会导致功能和耐久性降低。通过人工纳米材料复制天然酶的功能来对抗生物污垢具有很大的吸引力，但由于活性位点密度低，主要还是受到催化活性和特异性差的挑战。在这里，展示了一种创新的策略，即在氧化锆上稳定高密度的超小氧化铈簇，以防止生物污垢。受益于独特的结构，CeO@ZrO 纳米酶可以通过丰富的缺陷和表面强酸位显著提高过卤氧化物酶模拟活性，从而促进溴化物与 H2O2 的氧化生成杀菌性次溴酸，与原始 CeO2 相比，表现出令人印象深刻的抗菌和抗生物污垢能力。这项工作有望为各种靶向催化应用的簇催化剂的合理设计开辟新途径。
