不同骨成熟度分组患者的唾液 IGF-1、IGFBP-3 和 CTX 与牙周状况的比较。
Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups.
出版信息
Oral Health Prev Dent. 2022 Mar 14;20:103-112. doi: 10.3290/j.ohpd.b2805419.
PURPOSE
To compare the levels of salivary IGF-1, IGFBP-3, and CTX with periodontal status among patients belonging to various skeletal maturity groups.
MATERIALS AND METHODS
This cross-sectional study was conducted on 80 participants 6 to 25 years of age. Based on skeletal maturity, the participants were categorised into 3 different stages: prepubertal, pubertal, and post-pubertal stages. The periodontal status of the participants was assessed using the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). The saliva samples were examined for IGF-1, IGFBP-3, and CTX using the respective ELISA kits. One-way ANOVA was used to determine statistically significant differences of means across the study groups for continuous variables.
RESULTS
The study demonstrated statistically significant differences for the parameters OHI-S, bleeding on probing, PPD, CPI, and CAL (p < 0.05) depending on skeletal maturity stage. ANOVA test showed a statistically significant difference by stage in IGF-1, IGFPB3, and CTX (p < 0.01).
CONCLUSION
An association exists between periodontal status and levels of salivary IGF-1, IGFBP-3, and CTX in patients belonging to various skeletal maturity groups.
目的
比较不同骨骼成熟阶段患者的唾液 IGF-1、IGFBP-3 和 CTX 水平与牙周状况。
材料与方法
本横断面研究纳入了 80 名 6 至 25 岁的参与者。根据骨骼成熟度，参与者被分为 3 个不同阶段：青春前期、青春期和青春后期。使用简化口腔卫生指数（OHI-S）、探诊出血（BOP）、探诊牙周袋深度（PPD）、临床附着丧失（CAL）和社区牙周指数（CPI）评估参与者的牙周状况。使用相应的 ELISA 试剂盒检测唾液样本中的 IGF-1、IGFBP-3 和 CTX。使用单因素方差分析（ANOVA）比较研究组间连续变量的均值是否存在统计学差异。
结果
研究表明，根据骨骼成熟阶段，OHI-S、探诊出血、PPD、CPI 和 CAL 等参数存在统计学差异（p<0.05）。ANOVA 检验显示，IGF-1、IGFBP-3 和 CTX 水平在不同骨骼成熟阶段存在统计学差异（p<0.01）。
结论
在不同骨骼成熟阶段的患者中，牙周状况与唾液 IGF-1、IGFBP-3 和 CTX 水平之间存在关联。
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