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中国钢铁工人失眠与亚临床动脉粥样硬化的关联:一项横断面调查

Association between insomnia and subclinical atherosclerosis among Chinese steelworkers: a cross-sectional survey.

作者信息

Wang Lihua, Zhang Shengkui, Yu Miao, Yuan Juxiang

机构信息

Department of Epidemiology and Health Statistics, School of Public Health. North China University of Science and Technology, Tangshan, Hebei Province, China.

出版信息

Arch Public Health. 2022 Mar 14;80(1):80. doi: 10.1186/s13690-022-00834-1.

Abstract

BACKGROUND

Insomnia is a common prevalent sleep disorder. Difficulty maintaining sleep or poor in quality in insomnia caused by disrupted or misaligned circadian rhythms may play an important role in the development of atherosclerosis. This study aimed to examine the association between insomnia and subclinical atherosclerosis in Chinese steelworkers.

METHODS

A total of 3240 subjects from a large enterprise located in northern China were included in this study. The Athens Insomnia Scale (AIS) was used to assess the status of insomnia. Subclinical atherosclerosis was evaluated using ultrasonographic measurements of carotid plaque. Multivariable logistic regression was used to identify association between insomnia and carotid atherosclerosis.

RESULTS

The overall prevalence of insomnia and carotid plaque were 35.3 and 31.7% in the study population. Compared with non-insomnia workers, significantly increased odds of carotid plaque were observed among insomnia workers after adjusting for potential confounders, odds ratio (OR) = 1.38, 95% confidence interval (CI): 1.17 to 1.63. Exposure to current shift work and insomnia simultaneously can significantly elevated the odds of carotid plaque.

CONCLUSION

Insomnia is associated with elevated odds of carotid atherosclerosis in male steelworkers. Insomnia problems of workers should receive further attention in occupational worker health interventions.

摘要

背景

失眠是一种常见的普遍性睡眠障碍。昼夜节律紊乱或失调导致的失眠中,维持睡眠困难或睡眠质量差可能在动脉粥样硬化的发展中起重要作用。本研究旨在探讨中国钢铁工人失眠与亚临床动脉粥样硬化之间的关联。

方法

本研究纳入了来自中国北方一家大型企业的3240名受试者。采用雅典失眠量表(AIS)评估失眠状况。通过超声测量颈动脉斑块来评估亚临床动脉粥样硬化。采用多变量逻辑回归分析来确定失眠与颈动脉粥样硬化之间的关联。

结果

研究人群中失眠和颈动脉斑块的总体患病率分别为35.3%和31.7%。在调整潜在混杂因素后,与非失眠工人相比,失眠工人中颈动脉斑块的患病几率显著增加,优势比(OR)=1.38,95%置信区间(CI):1.17至1.63。同时暴露于当前轮班工作和失眠会显著增加颈动脉斑块的患病几率。

结论

在男性钢铁工人中,失眠与颈动脉粥样硬化的患病几率升高有关。工人的失眠问题在职业健康干预中应得到进一步关注。

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The changing landscape of atherosclerosis.动脉粥样硬化的变化格局。
Nature. 2021 Apr;592(7855):524-533. doi: 10.1038/s41586-021-03392-8. Epub 2021 Apr 21.
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2016 Chinese guidelines for the management of dyslipidemia in adults.《2016年中国成人血脂异常防治指南》
J Geriatr Cardiol. 2018 Jan;15(1):1-29. doi: 10.11909/j.issn.1671-5411.2018.01.011.

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