Murdoch Children's Research Institute, Parkville, VIC, Australia.
Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Sci Rep. 2022 Mar 14;12(1):4353. doi: 10.1038/s41598-022-08190-4.
Accurate information on dose, frequency and timing of maternal alcohol consumption is critically important when investigating fetal risks from prenatal alcohol exposure. Identification of distinct alcohol use behaviours can also assist in developing directed public health messages about possible adverse child outcomes, including Fetal Alcohol Spectrum Disorder. We aimed to determine group-based trajectories of time-specific, unit-level, alcohol consumption using data from 1458 pregnant women in the Asking Questions about Alcohol in Pregnancy (AQUA) longitudinal study in Melbourne, Australia. Six alcohol consumption trajectories were identified incorporating four timepoints across gestation. Labels were assigned based on consumption in trimester one and whether alcohol use was continued throughout pregnancy: abstained (33.8%); low discontinued (trimester one) (14.4%); moderate discontinued (11.7%); low sustained (13.0%); moderate sustained (23.5%); and high sustained (3.6%). Median weekly consumption in trimester one ranged from 3 g (low discontinued) to 184 g of absolute alcohol (high sustained). Alcohol use after pregnancy recognition decreased dramatically for all sustained drinking trajectories, indicating some awareness of risk to the unborn child. Further, specific maternal characteristics were associated with different trajectories, which may inform targeted health promotion aimed at reducing alcohol use in pregnancy.
准确的剂量、频率和母亲饮酒时间信息对于研究产前酒精暴露对胎儿的风险至关重要。识别不同的饮酒行为也有助于制定针对公共卫生的信息，以了解可能对儿童产生的不良后果，包括胎儿酒精谱系障碍。我们的目的是使用来自澳大利亚墨尔本的酒精与妊娠询问（AQUA）纵向研究中的 1458 名孕妇的数据，确定特定时间、单位水平的基于群组的饮酒轨迹。在整个妊娠期间持续饮酒的情况下，根据妊娠第一期的饮酒量和是否继续饮酒，确定了六个酒精消费轨迹：不饮酒（33.8%）；低量不持续（妊娠第一期）（14.4%）；中量不持续（11.7%）；低量持续（13.0%）；中量持续（23.5%）；高量持续（3.6%）。妊娠第一期的每周中位数酒精摄入量从 3 克（低量不持续）到 184 克绝对酒精（高量持续）不等。所有持续饮酒轨迹的孕妇在妊娠确诊后饮酒量均大幅下降，这表明她们对胎儿的风险有一定的认识。此外，不同的轨迹与特定的产妇特征有关，这可能为减少妊娠期间饮酒的有针对性的健康促进提供信息。
