前列腺素E2在胃肠道癌进展中的作用
Role of Prostaglandin E2 in the Progression of Gastrointestinal Cancer.
作者信息
Wilson David Jay, DuBois Raymond N
机构信息
College of Medicine, Medical University of South Carolina, Charleston, South Carolina.
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.
出版信息
Cancer Prev Res (Phila). 2022 Jun 2;15(6):355-363. doi: 10.1158/1940-6207.CAPR-22-0038.
Abstract
Chronic inflammation is a well-established risk factor for several diseases, including cancer. It influences tumor cell biology and the type and density of immune cells in the tumor microenvironment (TME), promoting cancer development. While proinflammatory cytokines and chemokines modulate cancer development, emerging evidence has shown that prostaglandin E2 (PGE2) is a known mediator connecting chronic inflammation to cancerization. This review highlights recent advances in our understanding of how the elevation of PGE2 production promotes gastrointestinal cancer initiation, progression, invasion, metastasis, and recurrence, including modulation of immune checkpoint signaling and the type and density of immune cells in the tumor/tissue microenvironment.
摘要
慢性炎症是包括癌症在内的多种疾病公认的危险因素。它影响肿瘤细胞生物学以及肿瘤微环境（TME）中免疫细胞的类型和密度，促进癌症发展。虽然促炎细胞因子和趋化因子可调节癌症发展，但新出现的证据表明，前列腺素E2（PGE2）是将慢性炎症与癌变联系起来的已知介质。本综述重点介绍了我们在理解PGE2产生增加如何促进胃肠道癌症的起始、进展、侵袭、转移和复发方面的最新进展，包括免疫检查点信号的调节以及肿瘤/组织微环境中免疫细胞的类型和密度。
相似文献
1
Role of Prostaglandin E2 in the Progression of Gastrointestinal Cancer.前列腺素E2在胃肠道癌进展中的作用
Cancer Prev Res (Phila). 2022 Jun 2;15(6):355-363. doi: 10.1158/1940-6207.CAPR-22-0038.
2
Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer.前列腺素 E2/EP 信号在结直肠癌肿瘤微环境中的作用。
Int J Mol Sci. 2019 Dec 11;20(24):6254. doi: 10.3390/ijms20246254.
3
Role of prostanoids in gastrointestinal cancer.前列腺素在胃肠道癌中的作用。
J Clin Invest. 2018 Jul 2;128(7):2732-2742. doi: 10.1172/JCI97953. Epub 2018 May 7.
4
Cyclooxygenases and Prostaglandins in Tumor Immunology and Microenvironment of Gastrointestinal Cancer.环氧化酶和前列腺素在胃肠道癌症的肿瘤免疫学和微环境中的作用
Gastroenterology. 2021 Dec;161(6):1813-1829. doi: 10.1053/j.gastro.2021.09.059. Epub 2021 Oct 2.
5
Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2 and Toll-like receptor/MyD88 pathways.胃癌中的炎症：COX-2/前列腺素E2与Toll样受体/髓样分化因子88信号通路的相互作用
Cancer Sci. 2016 Apr;107(4):391-7. doi: 10.1111/cas.12901. Epub 2016 Mar 18.
6
Prostaglandin E2 in neuroblastoma: Targeting synthesis or signaling?神经母细胞瘤中的前列腺素 E2：针对合成还是信号转导？
Biomed Pharmacother. 2022 Dec;156:113966. doi: 10.1016/j.biopha.2022.113966. Epub 2022 Nov 3.
7
An inflammatory mediator, prostaglandin E2, in colorectal cancer.结直肠癌中的炎症介质：前列腺素 E2。
Cancer J. 2013 Nov-Dec;19(6):502-10. doi: 10.1097/PPO.0000000000000003.
8
Prostaglandin E Receptor 4 Antagonist in Cancer Immunotherapy: Mechanisms of Action.前列腺素 E 受体 4 拮抗剂在癌症免疫治疗中的作用机制。
Front Immunol. 2020 Mar 10;11:324. doi: 10.3389/fimmu.2020.00324. eCollection 2020.
9
Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice.前列腺素 E2 促进小鼠结直肠癌干细胞的扩增和转移。
Gastroenterology. 2015 Dec;149(7):1884-1895.e4. doi: 10.1053/j.gastro.2015.07.064. Epub 2015 Aug 7.
10
Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.多药耐药相关蛋白4（MRP4）可输出前列腺素E2（PGE2），并促进基底样/三阴性乳腺癌的转移。
Oncotarget. 2017 Jan 24;8(4):6540-6554. doi: 10.18632/oncotarget.14145.
引用本文的文献
1
Neutrophils unveiled in chronic lymphocytic leukemia.慢性淋巴细胞白血病中发现的中性粒细胞。
Front Immunol. 2025 Aug 20;16:1609754. doi: 10.3389/fimmu.2025.1609754. eCollection 2025.
2
Lipid Metabolism in Gastrointestinal Malignancies: Exploring Dysregulation, Biomarkers, and Treatment Strategies.胃肠道恶性肿瘤中的脂质代谢：探索失调、生物标志物和治疗策略
Cancer Med. 2025 May;14(10):e70975. doi: 10.1002/cam4.70975.
3
Exploring the Cytotoxic Activity of Dillenia serrata Thunb. Leaf Extracts: An In Vitro and In Silico Investigation.探索锯叶榴莲叶提取物的细胞毒性活性：一项体外和计算机模拟研究。
Asian Pac J Cancer Prev. 2025 Mar 1;26(3):1043-1051. doi: 10.31557/APJCP.2025.26.3.1043.
4
Alternative Splicing at the Crossroad of Inflammatory Bowel Diseases and Colitis-Associated Colon Cancer.炎症性肠病与结肠炎相关结肠癌交叉路口的可变剪接
Cancers (Basel). 2025 Jan 11;17(2):219. doi: 10.3390/cancers17020219.
5
Utilizing Saliva Metabolomics for Diagnosing Gastric Cancer and Exploring the Changes in Saliva Metabolites After Surgery.利用唾液代谢组学诊断胃癌并探索术后唾液代谢物的变化。
Onco Targets Ther. 2024 Nov 6;17:933-948. doi: 10.2147/OTT.S482767. eCollection 2024.
6
PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells.PTGER4 信号转导调节直肠上皮细胞中的 IIa 类 HDAC 功能和 SPINK4 mRNA 水平。
Cell Commun Signal. 2024 Oct 13;22(1):493. doi: 10.1186/s12964-024-01879-1.
7
Evaluation of Periodontal Clinicoradiographic Status and Whol Salivary Prostaglandin E2 Levels among Users of Water Pipe and Cigarettes.评价水烟使用者与香烟使用者的牙周临床影像学状况和全唾液前列腺素 E2 水平。
Oral Health Prev Dent. 2024 Jul 26;22:341-348. doi: 10.3290/j.ohpd.b5629079.
8
Correlation between whole salivary prostaglandin E and hemoglobin A1c levels among type-2 diabetic and non-diabetic patients with periodontal inflammation.2 型糖尿病伴或不伴牙周炎患者全唾液前列腺素 E 与血红蛋白 A1c 水平的相关性。
BMC Oral Health. 2024 Feb 23;24(1):266. doi: 10.1186/s12903-024-04032-z.
9
PPARα Agonism Enhances Immune Response to Radiotherapy While Dietary Oleic Acid Results in Counteraction.过氧化物酶体增殖物激活受体 α 激动剂增强放射治疗的免疫反应，而膳食油酸则产生拮抗作用。
Clin Cancer Res. 2024 May 1;30(9):1916-1933. doi: 10.1158/1078-0432.CCR-23-3433.
10
Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing Agents.一些新型3-芳基-2-硫代-2,3-二氢喹唑啉-4(1)-酮和3-芳基-2-(苄硫基)喹唑啉-4(3)-酮作为抗氧化剂、COX-2、LDHA、α-葡萄糖苷酶和α-淀粉酶抑制剂以及抗结肠癌和凋亡诱导剂的合成与生物学评价
Pharmaceuticals (Basel). 2023 Oct 1;16(10):1392. doi: 10.3390/ph16101392.
本文引用的文献
1
Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer.阿司匹林激活炎症消退途径，以重新编程结肠炎相关结直肠癌中的T细胞和巨噬细胞反应。
Sci Adv. 2022 Feb 4;8(5):eabl5420. doi: 10.1126/sciadv.abl5420. Epub 2022 Feb 2.
2
COX-2 Inhibitors Decrease Expression of PD-L1 in Colon Tumors and Increase the Influx of Type I Tumor-infiltrating Lymphocytes.COX-2 抑制剂降低结肠肿瘤中 PD-L1 的表达并增加 I 型肿瘤浸润淋巴细胞的流入。
Cancer Prev Res (Phila). 2022 Apr 1;15(4):225-231. doi: 10.1158/1940-6207.CAPR-21-0227.
3
Cyclooxygenases and Prostaglandins in Tumor Immunology and Microenvironment of Gastrointestinal Cancer.环氧化酶和前列腺素在胃肠道癌症的肿瘤免疫学和微环境中的作用
Gastroenterology. 2021 Dec;161(6):1813-1829. doi: 10.1053/j.gastro.2021.09.059. Epub 2021 Oct 2.
4
Systematic review with meta-analysis: The effects of non-steroidal anti-inflammatory drugs and anti-platelet therapy on the incidence and recurrence of hepatocellular carcinoma.系统评价与荟萃分析：非甾体抗炎药和抗血小板治疗对肝细胞癌发生率和复发率的影响。
Aliment Pharmacol Ther. 2021 Aug;54(4):356-367. doi: 10.1111/apt.16515. Epub 2021 Jul 11.
5
Combination of EP antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells.EP 拮抗剂 MF-766 与抗 PD-1 联合通过调节淋巴细胞和髓样细胞增强抗肿瘤疗效。
Oncoimmunology. 2021 Mar 18;10(1):1896643. doi: 10.1080/2162402X.2021.1896643.
6
Aspirin Use Is Associated with a Reduced Incidence of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.阿司匹林的使用与肝细胞癌发病率的降低有关：系统评价和荟萃分析。
Hepatol Commun. 2020 Nov 13;5(1):133-143. doi: 10.1002/hep4.1640. eCollection 2021 Jan.
7
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer.重编程抑制性髓系细胞有助于结直肠癌的免疫治疗。
EMBO Mol Med. 2021 Jan 11;13(1):e12798. doi: 10.15252/emmm.202012798. Epub 2020 Dec 7.
8
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE-receptor E-type 4 (EP4), in patients with advanced cancers.E7046（一种前列腺素 E 受体 E 型 4（EP4）拮抗剂）在晚期癌症患者中的首次人体 I 期研究。
J Immunother Cancer. 2020 Jun;8(1). doi: 10.1136/jitc-2019-000222.
9
Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019.阿司匹林与结直肠癌和其他消化道癌症风险：更新的荟萃分析至 2019 年。
Ann Oncol. 2020 May;31(5):558-568. doi: 10.1016/j.annonc.2020.02.012. Epub 2020 Apr 1.
10
New insights into the functions of Cox-2 in skin and esophageal malignancies.探讨 Cox-2 在皮肤和食管恶性肿瘤中的功能新见解。
Exp Mol Med. 2020 Apr;52(4):538-547. doi: 10.1038/s12276-020-0412-2. Epub 2020 Apr 1.
Zotero 插件