Department of Pediatrics, Dokuz Eylul University Hospital, Division of Allergy, Inciralti, Izmir, Turkey.
Ann Thorac Med. 2011 Oct;6(4):227-30. doi: 10.4103/1817-1737.84778.
The aim of this study is to evaluate the relationship between acute exacerbations and the mean platelet volume (MPV) trend in children with cystic fibrosis (CF), to predict the exacerbations.
A total of 46 children with CF and 37 healthy children were enrolled in the study. White blood cell count (WBC), hemoglobin level, platelet count, mean platelet volume (MPV), and mean corpuscular volume (MCV) were retrospectively recorded.
Our study population consisted of 25 (54.3%) males and 21 (45.7%) females with CF and 20 (54.0%) males and 17 (46.0%) females in the healthy control group. The mean age of the CF patients was 6.32 ± 4.9 years and that of the healthy subjects was 7.02 ± 3.15 years. In the acute exacerbation period of CF, the MPV values were lower and WBC and platelet counts were higher than those in the healthy controls (P = 0.00, P = 0.00, P = 0.00, respectively). Besides, in acute exacerbation, the MPV values were lower and the WBC count was higher than the values in the non-exacerbation period (P 0= 0.01, P = 0.00, respectively). In the non-exacerbation period MPV was lower and platelet count was higher when compared to healthy subjects (P = 0.02, P = 0.04, respectively).
This study suggests that MPV might be used as a simple, cost effective, diagnostic, predictive indicator for platelet activation in pediatric CF patients related to chronic inflammation, which might be helpful to discriminate or estimate exacerbations.
本研究旨在评估儿童囊性纤维化（CF）急性加重与平均血小板体积（MPV）趋势的关系，以预测加重。
共纳入 46 例 CF 患儿和 37 例健康儿童。回顾性记录白细胞计数（WBC）、血红蛋白水平、血小板计数、平均血小板体积（MPV）和平均红细胞体积（MCV）。
本研究人群包括 25 名（54.3%）男性和 21 名（45.7%）女性 CF 患儿，以及 20 名（54.0%）男性和 17 名（46.0%）女性健康对照组。CF 患者的平均年龄为 6.32±4.9 岁，健康受试者的平均年龄为 7.02±3.15 岁。在 CF 的急性加重期，MPV 值较低，WBC 和血小板计数较高，与健康对照组相比（P=0.00，P=0.00，P=0.00，分别）。此外，在急性加重期，MPV 值较低，WBC 计数高于非加重期（P=0.01，P=0.00，分别）。在非加重期，MPV 较低，血小板计数较高，与健康对照组相比（P=0.02，P=0.04，分别）。
本研究表明，MPV 可能作为一种简单、经济有效的诊断、预测指标，用于预测儿童 CF 患者与慢性炎症相关的血小板活化，有助于鉴别或估计加重。
