Department of Internal Medicine, Division of Hematology and Oncology, and.
Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
J Clin Invest. 2022 Mar 15;132(6). doi: 10.1172/JCI143762.
Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as part of a next generation of immunotherapies to treat patients with metastatic disease. Therefore, it is essential for us to examine how metastatic cancer cells and NK cells interact with each other throughout the metastatic cascade. In this Review, we highlight the recent body of work that has begun to answer these questions. We explore how the unique biology of cancer cells at each stage of metastasis alters fundamental NK cell biology, including how cancer cells can evade immunosurveillance and co-opt NK cells into cells that promote metastasis. We also discuss the translational potential of this knowledge.
自然杀伤 (NK) 细胞是先天免疫细胞，对机体的抗肿瘤和抗转移防御至关重要。因此，正在开发新的治疗方法，利用 NK 细胞作为下一代免疫疗法的一部分，来治疗转移性疾病患者。因此，我们必须研究转移性癌细胞和 NK 细胞在整个转移级联过程中是如何相互作用的。在这篇综述中，我们重点介绍了最近开始回答这些问题的大量研究工作。我们探讨了转移性癌细胞在每个转移阶段的独特生物学如何改变 NK 细胞生物学的基本原理，包括癌细胞如何逃避免疫监视以及如何将 NK 细胞招募为促进转移的细胞。我们还讨论了这方面知识的转化潜力。
