Su Juanjuan, Lu Shuang, Wei Zheng, Li Bo, Li Jingjing, Sun Jing, Liu Kai, Zhang Hongjie, Wang Fan
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Small. 2022 Apr;18(16):e2200897. doi: 10.1002/smll.202200897. Epub 2022 Mar 15.
Synergistic therapy for malignant tumors has been developed in the past. However, several disadvantages that are associated with the applied inorganic nanoagents cannot be avoided, including intrinsic systemic toxicity, immunosuppression, and low therapeutic efficiency. Herein, a biocompatible, multifunctional, inorganic nanoagent that simultaneously integrates chemodynamic, starvation, and photothermal therapies is developed. This nanoagent effectively converts endogenous H O into highly toxic hydroxyl radicals via the Fenton reaction. Self-reinforced cancer therapy is achieved via the scavenging of intracellular glutathione and glucose. The encapsulation of nanoagent by erythrocytes drastically reduces its immune recognition by macrophages. Thus, an augmented anti-tumor immune response is realized. Moreover, in contrast to traditional inorganic chemodynamic nanomaterials, the nanoagent has outstanding photothermal efficiency. Therefore, the present system exhibits an effective tumor therapeutic outcome. This work may facilitate a new pathway for the development of highly efficacious synergetic therapies.
过去已经开发出用于恶性肿瘤的协同疗法。然而，所应用的无机纳米剂存在一些不可避免的缺点，包括内在的全身毒性、免疫抑制和低治疗效率。在此，开发了一种生物相容性、多功能的无机纳米剂，它同时整合了化学动力学、饥饿和光热疗法。这种纳米剂通过芬顿反应有效地将内源性H₂O转化为剧毒的羟基自由基。通过清除细胞内谷胱甘肽和葡萄糖实现自我强化的癌症治疗。红细胞对纳米剂的包裹大大降低了巨噬细胞对其的免疫识别。因此，实现了增强的抗肿瘤免疫反应。此外，与传统的无机化学动力学纳米材料相比，该纳米剂具有出色的光热效率。因此，本系统展现出有效的肿瘤治疗效果。这项工作可能为开发高效协同疗法开辟一条新途径。
