Wei Zheng, Liu Yawei, Li Bo, Li Jingjing, Lu Shuang, Xing Xiwen, Liu Kai, Wang Fan, Zhang Hongjie
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China.
Light Sci Appl. 2022 Jun 10;11(1):175. doi: 10.1038/s41377-022-00864-y.
Brain diseases, including tumors and neurodegenerative disorders, are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition, efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess unique optical properties, superior magnetism, and high X-ray absorption abilities, enabling high-resolution imaging of the brain through magnetic resonance imaging, computed tomography imaging, and fluorescence imaging technologies. In addition, rare-earth based materials can be used to detect, treat, and regulate of brain diseases through fine modulation of their structures and functions. Importantly, rare-earth based materials coupled with biomolecules such as antibodies, peptides, and drugs can overcome the blood-brain barrier and be used for targeted treatment. Herein, this review highlights the rational design and application of rare-earth based materials in brain imaging, therapy, monitoring, and neuromodulation. Furthermore, the development prospect of rare-earth based materials is briefly introduced.
包括肿瘤和神经退行性疾病在内的脑部疾病是最严重的健康问题之一。需要非侵入性高分辨率成像方法来获取大脑的解剖结构和信息。此外，治疗脑部疾病还需要高效的诊断技术。稀土基材料具有独特的光学性质、卓越的磁性和高X射线吸收能力，能够通过磁共振成像、计算机断层扫描成像和荧光成像技术对大脑进行高分辨率成像。此外，稀土基材料可以通过对其结构和功能的精细调控来检测、治疗和调节脑部疾病。重要的是，稀土基材料与抗体、肽和药物等生物分子结合，可以克服血脑屏障，用于靶向治疗。在此，本综述重点介绍了稀土基材料在脑成像、治疗、监测和神经调节方面的合理设计与应用。此外，还简要介绍了稀土基材料的发展前景。
