杜氏肌营养不良症患者在接受无创通气时的呼气阻塞：一种新阻塞模式的分步分析。
Expiratory obstruction in patients with Duchenne muscular dystrophy under non-invasive ventilation: A step-by-step analysis of a new obstructive pattern.
机构信息
Département de Physiologie, Explorations Fonctionnelles, Unité des Pathologies du Sommeil, 26930AP-HP, Hôpital Raymond Poincaré, Garches, France.
30133Université Versailles-Saint-Quentin-en-Yvelines, END:ICAP U1179 Inserm, UFR des Sciences de la Sante-Simone-Veil, Versailles, France.
出版信息
Chron Respir Dis. 2021 Jan-Dec;18:14799731211036901. doi: 10.1177/14799731211036901.
PURPOSE
Non-invasive ventilation (NIV) is the reference standard for managing chronic hypoventilation in patients with Duchenne muscular dystrophy (DMD). In these patients, upper airway obstruction under NIV may compromise efficacy and adherence. We aim to describe a novel pattern of expiratory obstructive events occurring during nocturnal barometric NIV.
METHODS
We retrospectively included all patients with DMD who underwent full-night polygraphy during NIV as part of their usual follow-up between May 2018 and July 2019.
RESULTS
We provide a step-by-step description of this previously undescribed pattern of obstruction. Expiratory obstructions lead to end-inspiratory breath-holding and impossibility to take another inspiratory breath with a barometric mode until expiration occurs. These events were observed in 4 (36%) of 11 DMD patients under barometric NIV.
CONCLUSION
Expiratory obstructions may be common in DMD patients receiving NIV and should be sought out routinely. This previously undescribed variant of obstructive event must be identified.
目的
无创通气（NIV）是治疗杜氏肌营养不良症（DMD）患者慢性低通气的标准方法。在这些患者中，NIV 下上气道阻塞可能会影响疗效和依从性。我们旨在描述一种在夜间气压 NIV 期间发生的新型呼气阻塞事件模式。
方法
我们回顾性纳入了 2018 年 5 月至 2019 年 7 月期间在接受 NIV 期间进行了整夜多导睡眠图检查的所有 DMD 患者。
结果
我们提供了这种以前未描述的阻塞模式的逐步描述。呼气阻塞导致吸气暂停，并且在呼气发生之前，无法使用气压模式进行另一次吸气。在 11 名接受气压 NIV 的 DMD 患者中，有 4 名（36%）观察到这种呼气阻塞事件。
结论
在接受 NIV 的 DMD 患者中，呼气阻塞可能很常见，应常规寻找。必须识别这种以前未描述的阻塞事件变体。
Zotero 插件