Department of Psychology, University of North Florida, Jacksonville, Florida, USA.
Biomedical Sciences Program, University of North Florida, Jacksonville, Florida, USA.
Hum Brain Mapp. 2022 Jun 15;43(9):2972-2991. doi: 10.1002/hbm.25830. Epub 2022 Mar 15.
Naturalistic imaging paradigms, in which participants view complex videos in the scanner, are increasingly used in human cognitive neuroscience. Videos evoke temporally synchronized brain responses that are similar across subjects as well as within subjects, but the reproducibility of these brain responses across different data acquisition sites has not yet been quantified. Here, we characterize the consistency of brain responses across independent samples of participants viewing the same videos in functional magnetic resonance imaging (fMRI) scanners at different sites (Indiana University and Caltech). We compared brain responses collected at these different sites for two carefully matched datasets with identical scanner models, acquisition, and preprocessing details, along with a third unmatched dataset in which these details varied. Our overall conclusion is that for matched and unmatched datasets alike, video-evoked brain responses have high consistency across these different sites, both when compared across groups and across pairs of individuals. As one might expect, differences between sites were larger for unmatched datasets than matched datasets. Residual differences between datasets could in part reflect participant-level variability rather than scanner- or data- related effects. Altogether our results indicate promise for the development and, critically, generalization of video fMRI studies of individual differences in healthy and clinical populations alike.
自然主义成像范式，参与者在扫描仪中观看复杂的视频，在人类认知神经科学中越来越多地被使用。视频引发了时间上同步的大脑反应，这些反应在不同的被试之间以及同一个被试的不同时间内是相似的，但这些大脑反应在不同的数据采集地点的可重复性尚未被量化。在这里，我们描述了在不同地点（印第安纳大学和加州理工学院）的功能磁共振成像（fMRI）扫描仪中观看相同视频的独立参与者样本的大脑反应的一致性。我们比较了这些不同地点采集的大脑反应，对于两个经过精心匹配的数据集，这些数据集具有相同的扫描仪模型、采集和预处理细节，以及第三个不匹配的数据集，其中这些细节有所不同。我们的总体结论是，对于匹配和不匹配的数据集，视频引发的大脑反应在这些不同的地点之间具有高度的一致性，无论是在组之间还是在个体对之间进行比较。正如人们可能预期的那样，不匹配数据集之间的差异大于匹配数据集之间的差异。数据集之间的剩余差异可能部分反映了参与者水平的变异性，而不是扫描仪或数据相关的影响。总的来说，我们的结果表明，对于健康和临床人群中个体差异的视频 fMRI 研究的发展，以及至关重要的推广，具有很大的希望。
