University of Gafsa, Faculty of Sciences, Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems - LBBEEO, Sidi Ahmed Zarrouk, Tunisia.
Universidade Federal do Vale do São Francisco - UNIVASF, Center for Studies and Research of Medicinal Plants - NEPLAME, Petrolina, PE, Brasil.
Braz J Biol. 2022 Mar 14;84:e255120. doi: 10.1590/1519-6984.255120. eCollection 2022.
This study aimed to determine the antiulcerogenic and antioxidant activities of Psyllium (Plantago ovata Forssk) seed ethanolic extract in rats. We assessed the antioxidant potential using free radical scavenging on DPPH, β-carotene bleaching activity, ferric reducing power, and hydroxyl radical scavenging activity. In the antiulcerogenic study, pre-treatment with Plantago ovata seeds ethanolic extract (POE) (400 mg/kg b.wt) significantly protected against ethanol-induced gastric ulcer in rats by decreasing the ulcer index value and preserving the integrity of the gastric mucosa. The oxidative stress status in the stomach tissues showed a significant increase in the antioxidant enzyme levels of superoxide dismutase, catalase, and glutathione peroxidase with a significant decrease in lipid peroxidation during pre-treatment with POE. In conclusion, the POE protects against gastric ulcer due to its antioxidant potential and presence of bioactive molecules.
本研究旨在确定车前草（Plantago ovata Forssk）种子乙醇提取物的抗溃疡和抗氧化活性在大鼠体内的作用。我们使用 DPPH 自由基清除、β-胡萝卜素漂白活性、铁还原能力和羟基自由基清除活性来评估抗氧化潜力。在抗溃疡研究中，车前草种子乙醇提取物（POE）（400mg/kg b.wt）预处理可通过降低溃疡指数值和保护胃黏膜完整性，显著减轻乙醇诱导的大鼠胃溃疡。胃组织的氧化应激状态显示，抗氧化酶超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的水平显著增加，而 POE 预处理时脂质过氧化作用显著降低。总之，POE 因其抗氧化潜力和生物活性分子的存在而具有保护胃免受溃疡的作用。
