Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA.
Department of Radiation Oncology H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA.
Exp Mol Med. 2022 Mar;54(3):207-215. doi: 10.1038/s12276-022-00739-7. Epub 2022 Mar 16.
It is well known that metabolism underlies T cell differentiation and functions. The pathways regulating T cell metabolism and function are interconnected, and changes in T cell metabolic activity directly impact the effector functions and fate of T cells. Thus, understanding how metabolic pathways influence immune responses and ultimately affect disease progression is paramount. Epigenetic and posttranslational modification mechanisms have been found to control immune responses and metabolic reprogramming. Sirtuins are NAD-dependent histone deacetylases that play key roles during cellular responses to a variety of stresses and have recently been reported to have potential roles in immune responses. Therefore, sirtuins are of significant interest as therapeutic targets to treat immune-related diseases and enhance antitumor immunity. This review aims to illustrate the potential roles of sirtuins in different subtypes of T cells during the adaptive immune response.
众所周知，代谢是 T 细胞分化和功能的基础。调节 T 细胞代谢和功能的途径相互关联，T 细胞代谢活性的变化会直接影响 T 细胞的效应功能和命运。因此，了解代谢途径如何影响免疫反应，最终影响疾病进展至关重要。已经发现表观遗传和翻译后修饰机制可以控制免疫反应和代谢重编程。Sirtuins 是 NAD 依赖性组蛋白去乙酰化酶，在细胞对各种应激的反应中发挥关键作用，最近有报道称它们在免疫反应中具有潜在作用。因此，Sirtuins 作为治疗靶点治疗与免疫相关的疾病和增强抗肿瘤免疫具有重要意义。本综述旨在阐明 Sirtuins 在适应性免疫反应中不同亚型 T 细胞中的潜在作用。
