Allied Health and Human Performance, University of South Australia, City East Campus, Corner of North Terrace and Frome Rd, Adelaide, SA, 5001, Australia.
Alliance for Research in Exercise, Nutrition and Activity, University of South Australia, Adelaide, Australia.
Eur J Appl Physiol. 2022 Jun;122(6):1397-1408. doi: 10.1007/s00421-022-04931-5. Epub 2022 Mar 16.
Exercise improves measures of cardiovascular (CV) health and function. But as traditional measures improve gradually, it can be difficult to identify the effectiveness of an exercise intervention in the short-term. Left ventricular global longitudinal strain (LVGLS) is a highly sensitive CV imaging measure that detects signs of myocardial dysfunction prior to more traditional measures, with reductions in LVGLS a strong prognostic indicator of future CV dysfunction and mortality. Due to its sensitivity, LVGLS may offer useful method of tracking the effectiveness of an exercise intervention on CV function in the short-term, providing practitioners useful information to improve patient care in exercise settings. However, the effect of exercise on LVGLS is unclear. This systematic review and meta-analysis aimed to determine the effect exercise has on LVGLS across a range of populations. Included studies assessed LVGLS pre-post an exercise intervention (minimum 2 weeks) in adults 18 years and over, and were published in English from 2000 onwards. Study-level random-effects meta-analyses were performed using Stata (v16.1) to calculate summary standardized mean differences (SMD) and 95% confidence intervals (CI). 39 studies met selection criteria, with 35 included in meta-analyses (1765 participants). In primary analyses, a significant improvement in LVGLS was observed in populations with CV disease (SMD = 0.59; 95% CI 0.16-1.02; p = 0.01), however, no significant effect of exercise was observed in CV risk factor and healthy populations. In populations with CV disease, LVGLS could be used as an early biomarker to determine the effectiveness of an exercise regime before changes in other clinical measures are observed.
运动可改善心血管 (CV) 健康和功能的各项指标。但随着传统指标逐渐改善，要确定运动干预的短期效果可能会变得很困难。左心室整体纵向应变 (LVGLS) 是一种高度敏感的 CV 成像指标，可在传统指标之前检测到心肌功能障碍的迹象，LVGLS 的降低是未来 CV 功能障碍和死亡的强有力预后指标。由于其敏感性，LVGLS 可能是一种有用的方法，可在短期内跟踪运动干预对 CV 功能的效果，为从业者提供有用的信息，以改善运动环境中的患者护理。然而，运动对 LVGLS 的影响尚不清楚。本系统评价和荟萃分析旨在确定运动对一系列人群的 LVGLS 的影响。纳入的研究评估了成年人（年龄 18 岁及以上）在进行运动干预（至少 2 周）前后的 LVGLS，这些研究均发表于 2000 年以后的英文期刊上。使用 Stata（v16.1）进行研究水平的随机效应荟萃分析，以计算汇总标准化均数差值（SMD）和 95%置信区间（CI）。有 39 项研究符合入选标准，其中 35 项研究被纳入荟萃分析（1765 名参与者）。在主要分析中，观察到患有 CV 疾病的人群的 LVGLS 有显著改善（SMD=0.59；95%CI 0.16-1.02；p=0.01），但在 CV 危险因素和健康人群中未观察到运动的显著效果。在患有 CV 疾病的人群中，LVGLS 可作为一种早期生物标志物，在观察到其他临床指标变化之前，确定运动方案的有效性。
