Rajput Rahul, Narkhede Jitendra, Naik Jitendra
University Institute of Chemical Technology, KBC North Maharashtra University, Jalgaon, 425001, India.
ADMET DMPK. 2019 Dec 21;8(1):1-15. doi: 10.5599/admet.724. eCollection 2020.
Nanogels are submicron-size aqueous dispersions of water-swollen particles, composed of nano-sized three-dimensional highly cross-linked networks of hydrophilic polymers. An active pharmaceutical agent or therapeutic agent with high or low molecular weight can be easily encapsulated into nanogels that can be delivered to the site of action via various routes, including oral, pulmonary, nasal, parenteral and intraocular routes, among others. Therapeutic agents encapsulated into nanogels improve the therapeutic activity in the biological environment. The application of different nanogels in drug delivery and recent clinical trial studies has been described concisely in this review.
纳米凝胶是水膨胀颗粒的亚微米级水分散体，由亲水性聚合物的纳米级三维高度交联网络组成。高分子量或低分子量的活性药物或治疗剂可以很容易地封装到纳米凝胶中，纳米凝胶可以通过各种途径递送至作用部位，包括口服、肺部、鼻腔、肠胃外和眼内途径等。封装到纳米凝胶中的治疗剂可提高生物环境中的治疗活性。本综述简要描述了不同纳米凝胶在药物递送中的应用及近期的临床试验研究。
