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Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases.

作者信息

Sekizuka Hiromitsu

机构信息

Department of Internal Medicine, FUJITSU Clinic, Kawasaki, Japan.

出版信息

Hypertens Res. 2022 May;45(5):772-774. doi: 10.1038/s41440-022-00891-7. Epub 2022 Mar 17.

DOI:10.1038/s41440-022-00891-7
PMID:35301451
Abstract
摘要

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Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases.尿酸、黄嘌呤氧化酶与血管损伤：黄嘌呤氧化还原酶抑制剂预防心血管疾病的潜力
Hypertens Res. 2022 May;45(5):772-774. doi: 10.1038/s41440-022-00891-7. Epub 2022 Mar 17.
2
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Uric acid reduction: a new paradigm in the management of cardiovascular risk?尿酸降低：心血管风险管理的新范式？
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Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.给草酸盐处理的小鼠施用葡萄籽原花青素可降低血清尿酸水平，并降低肝脏黄嘌呤脱氢酶/氧化酶活性。
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Xanthine oxidoreductase: A leading actor in cardiovascular disease drama.黄嘌呤氧化还原酶：心血管疾病剧目中的主角。
Redox Biol. 2021 Nov 24;48:102195. doi: 10.1016/j.redox.2021.102195.
2
Plasma Xanthine Oxidoreductase Activity Is Associated with a High Risk of Cardiovascular Disease in a General Japanese Population.血浆黄嘌呤氧化酶活性与日本普通人群心血管疾病的高风险相关。
Int J Environ Res Public Health. 2021 Feb 16;18(4):1894. doi: 10.3390/ijerph18041894.
3
New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity.
血清尿酸与心血管疾病患者全因和心血管死亡率的关系。
Sci Rep. 2024 Nov 4;14(1):26675. doi: 10.1038/s41598-024-76970-1.
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Melatonin supplementation counteracts fiber loss in knee ligaments of diabetes-induced rats.补充褪黑素可抵消糖尿病诱导大鼠膝关节韧带中的纤维损失。
Front Pharmacol. 2024 Jul 29;15:1399719. doi: 10.3389/fphar.2024.1399719. eCollection 2024.
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Modification of extracellular matrix proteins by oxidants and electrophiles.氧化剂和亲电物对细胞外基质蛋白的修饰。
Biochem Soc Trans. 2024 Jun 26;52(3):1199-1217. doi: 10.1042/BST20230860.
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Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance.甜橙皮中的柚皮苷通过调节黄嘌呤氧化酶/尿酸信号和维持氧化还原平衡来改善高脂饮食诱导的糖尿病大鼠的睾丸功能。
Lab Anim Res. 2024 Feb 18;40(1):5. doi: 10.1186/s42826-024-00188-5.
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Effects of uric acid on ischemic diseases, stratified by lipid levels: a drug-target, nonlinear Mendelian randomization study.尿酸对缺血性疾病的影响，按血脂水平分层：药物靶点、非线性孟德尔随机化研究。
Sci Rep. 2024 Jan 16;14(1):1338. doi: 10.1038/s41598-024-51724-1.
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Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism.抗生素诱导的肠道微生物群落失调对嘌呤代谢有功能影响。
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Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction.尿酸诱导内皮功能障碍的新机制：人血管内皮细胞氧化应激与肾素-血管紧张素系统的激活。
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