Tamai Y, Iwamoto M, Tsujimoto T
Brain Res. 1986 Aug 13;380(1):19-25. doi: 10.1016/0006-8993(86)91424-1.
Blink reflex responses evoked by electrical stimulation of the supraorbital nerve were examined using cats and the pathway of the blink reflex in the brainstem was elucidated. Both early response (ER) and late response (LR) were mediated by the main sensory trigeminal nucleus and the spinal trigeminal nucleus. However, a lesion of the main sensory trigeminal nucleus had less effect on the blink reflex than a lesion of the spinal trigeminal nucleus. The ER was mediated not only by the shorter disynaptic pathway of 3 neurons through the trigeminal nerve, the trigeminal nuclei and the facial nucleus but also by a polysynaptic pathway of 4 neurons. The interneurons were located between the trigeminal nuclei and the facial nucleus. Some of these interneurons participated in the production of both ER and LR. The area of the brainstem responsible for ER and LR of the blink reflex was the reticular formation from the rostral part of the medulla to the pons except the medial area around the median sulcus. The LR interneurons were distributed more widely than the ER interneurons.
使用猫来检测由眶上神经电刺激诱发的瞬目反射反应，并阐明了脑干中瞬目反射的通路。早期反应（ER）和晚期反应（LR）均由三叉神经主感觉核和三叉神经脊髓核介导。然而，三叉神经主感觉核的损伤对瞬目反射的影响小于三叉神经脊髓核的损伤。ER不仅由通过三叉神经、三叉神经核和面神经核的3个神经元的较短双突触通路介导，还由4个神经元的多突触通路介导。中间神经元位于三叉神经核和面神经核之间。其中一些中间神经元参与了ER和LR的产生。负责瞬目反射ER和LR的脑干区域是从延髓前部到脑桥的网状结构，但不包括中央沟周围的内侧区域。LR中间神经元的分布比ER中间神经元更广泛。
