Hiraoka M, Shimamura M
Brain Res. 1977 Apr 15;125(2):265-75. doi: 10.1016/0006-8993(77)90620-5.
Neural mechanisms of the blinking reflex elicited by corneal stimulation were analyzed with electrophysiological techniques in the encéphale isolé cat. (1) Mechanical and electrical stimulation elicited two successive responses of the electromyogram of the orbicularis oculi. Neuromuscular unit studies revealed that the same unit was excited twice and that the latencies of both responses corresponded well with the two EMG responses. (2) The late response was easily affected by anoxia and pentobarbital administration, and was also abolished with the slow-wave sleep stage. (3) Both responses were abolished by ipsilateral transection between the inferior colliculus and genu of the facial nerve. (4) Compared with the latencies of the EMG, the sum of the conduction times through the sensory trigeminal nucleus and the facial nucleus corresponded with the latency of the early response. The sum of the conduction times through the reticular formation, added to the former reflex arc, corresponded to the latency of the late response. (5) The reflex pathway of the early response is consistent with a three-neuron arc passing through the sensory trigeminal nucleus and the facial nucleus. The late response may employ a multisynaptic arc passing through the brain stem medial reticular formation between the sensory trigeminal nucleus and the facial nucleus.
采用电生理技术，在孤立脑猫中分析了角膜刺激引发的眨眼反射的神经机制。（1）机械和电刺激引发眼轮匝肌肌电图的两个连续反应。神经肌肉单位研究表明，同一单位被两次兴奋，且两个反应的潜伏期与两个肌电图反应高度相符。（2）晚期反应容易受到缺氧和戊巴比妥给药的影响，并且在慢波睡眠阶段也会消失。（3）两个反应均通过在下丘与面神经膝之间进行同侧横断而被消除。（4）与肌电图的潜伏期相比，通过感觉三叉神经核和面神经核的传导时间总和与早期反应的潜伏期相符。通过网状结构的传导时间总和，加上前者的反射弧，与晚期反应的潜伏期相符。（5）早期反应的反射通路与通过感觉三叉神经核和面神经核的三神经元弧一致。晚期反应可能采用通过感觉三叉神经核和面神经核之间的脑干内侧网状结构的多突触弧。
