Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Universidad Autónoma de la Ciudad de México, Mexico City, Mexico.
Sci Rep. 2022 Mar 18;12(1):4662. doi: 10.1038/s41598-022-08501-9.
Prostate cancer and its treatment may induce muscle wasting. Body composition and muscle functionality are rarely assessed in patients with prostate cancer from developing countries due to the limited availability of high-quality equipment for routine diagnosis. This cross-sectional study evaluated the association between several simplistic techniques for assessing muscle mass and function with a more complex standard of reference for muscle wasting among Mexican men with prostate cancer. Muscle wasting was highly prevalent, yet it was presumably associated with aging rather than cancer and its treatment itself. The restricted availability of specific equipment in clinical settings with technological limitations supports using unsophisticated techniques as surrogate measurements for muscle wasting. The left-arm handgrip dynamometry displayed the highest correlation with the standard of reference and exhibited an acceptable predicted probability for muscle estimation. Combining several simplistic techniques may be preferable. We also developed and internally validated a manageable model that helps to identify elderly patients with prostate cancer at risk of muscle depletion and impairment. These findings promote the early recognition and treatment of muscle wasting alterations occurring among older adults with prostate cancer.
前列腺癌及其治疗可能会导致肌肉减少。由于用于常规诊断的高质量设备有限，来自发展中国家的前列腺癌患者很少评估身体成分和肌肉功能。这项横断面研究评估了几种用于评估肌肉质量和功能的简单技术与更复杂的肌肉减少标准参考值之间的关联，该标准参考值用于评估墨西哥男性前列腺癌患者的肌肉减少情况。肌肉减少的患病率很高，但它可能与衰老而不是癌症及其治疗本身有关。由于技术限制，临床环境中特定设备的可用性有限，因此支持使用不复杂的技术作为肌肉减少的替代测量方法。左手臂握力测力计与标准参考值的相关性最高，并表现出可接受的肌肉估计预测概率。结合几种简单的技术可能更可取。我们还开发并内部验证了一个易于管理的模型，该模型有助于识别有肌肉消耗和损伤风险的老年前列腺癌患者。这些发现促进了对老年前列腺癌患者中发生的肌肉减少改变的早期识别和治疗。
