Zeiler H J, Endermann R
Chemotherapy. 1986;32(5):468-72. doi: 10.1159/000238453.
A granuloma pouch model in mice was used to investigate the effect of ciprofloxacin in vivo on cells of Escherichia coli (Neumann) under stationary growth conditions. The animals were treated up to three times intraperitoneally with 2.5, 10 or 40 mg/kg ciprofloxacin 24 h after infection. The numbers of viable bacteria in the pouch exudate were determined over a period of 24 h. A rapid decline of more than 1 logarithmic unit of the number of colony forming units was observed after 2-4 h with all treatment schedules. The effect on stationary cells was more pronounced with the high dose of ciprofloxacin and also dependent on the frequency of treatment. Ciprofloxacin penetrated well into the pouch exudate and reached concentrations of 2.08 +/- 0.16 microgram/ml and 0.1 +/- 0.05 microgram/ml 2 h after treatment with 40 and 2.5 mg/kg, respectively. The results of this study demonstrate that ciprofloxacin is effective in the treatment of a local inflammatory abscess in mice harbouring a stationary population of E. coli.
采用小鼠肉芽肿袋模型研究环丙沙星在体内对处于稳定生长条件下的大肠杆菌（诺伊曼菌）细胞的作用。感染后24小时，给动物腹腔注射2.5、10或40mg/kg环丙沙星，最多治疗三次。在24小时内测定袋渗出液中活菌的数量。所有治疗方案在2 - 4小时后均观察到菌落形成单位数量快速下降超过1个对数单位。高剂量环丙沙星对静止细胞的作用更明显，且还取决于治疗频率。环丙沙星能很好地渗透到袋渗出液中，分别用40mg/kg和2.5mg/kg治疗2小时后，其浓度分别达到2.08±0.16微克/毫升和0.1±0.05微克/毫升。本研究结果表明，环丙沙星对携带稳定数量大肠杆菌的小鼠局部炎性脓肿治疗有效。
