McGiven A R, Hunt J S, Day W A, Bailey R R
J Clin Pathol. 1978 Jul;31(7):620-5. doi: 10.1136/jcp.31.7.620.
Tamm-Horsfall protein was detected within the capsular space by immunofluorescence in 7 of 72 consecutive patients on whom renal immunopathological studies were performed. Three patients showed prominent aggregates or crescentic collections affecting 30-50% glomeruli; the remaining four patients showed smaller aggregates between lobules. All patients showed pathological evidence of tubulointerstitial disease. It is suggested that Tamm-Horsfall protein in the capsular space is a sign of intratubular urinary backflow and that Tamm-Horsfall antiserum is a useful addition to the reagents used in the immunofluorescence study of renal biopsies.
在连续72例接受肾脏免疫病理研究的患者中，7例通过免疫荧光法在肾小囊腔内检测到了Tamm-Horsfall蛋白。3例患者出现显著的聚集物或新月形聚集体，累及30%-50%的肾小球；其余4例患者在小叶间可见较小的聚集物。所有患者均有肾小管间质疾病的病理证据。提示肾小囊腔内的Tamm-Horsfall蛋白是肾小管内尿液反流的标志，且Tamm-Horsfall抗血清是肾活检免疫荧光研究中所用试剂的有益补充。
