Xian Bo Shang, Chen Wang, Chang Liu, Hao Ran Yu, Hui Hui Guo, Ya Kun Zhu, Wu Kun Xie, Hai Tao Fan, Wen Dan Cheng
Anhui Medical University, Hefei, China.
Second Hospital of Anhui Medical University, Hefei, China.
Front Pharmacol. 2022 Mar 2;13:731756. doi: 10.3389/fphar.2022.731756. eCollection 2022.
Exosomes participate in many physiological and pathological processes by regulating cell-to-cell communication. This affects the etiology and development of diseases, such as osteoarthritis (OA). Although exosomes in the OA tissue microenvironment are involved in the progression of OA, exosomes derived from therapeutic cells represent a new therapeutic strategy for OA treatment. Recent studies have shown that exosomes participate in OA treatment by regulating the proliferation, apoptosis, inflammation, and extracellular matrix synthesis of chondrocytes. However, studies in this field are scant. This review summarizes the therapeutic properties of exosomes on chondrocytes in OA and their underlying molecular mechanisms. We also discuss the challenges and prospects of exosome-based OA treatment.
外泌体通过调节细胞间通讯参与多种生理和病理过程。这影响疾病的病因和发展，如骨关节炎（OA）。虽然OA组织微环境中的外泌体参与OA的进展，但治疗性细胞来源的外泌体代表了一种新的OA治疗策略。最近的研究表明，外泌体通过调节软骨细胞的增殖、凋亡、炎症和细胞外基质合成参与OA治疗。然而，该领域的研究较少。本综述总结了外泌体对OA中软骨细胞的治疗特性及其潜在分子机制。我们还讨论了基于外泌体的OA治疗的挑战和前景。
