Alkhalf Hamad, Almutairi Ashwag R, Almutairi Abeer, Almutairi Reem K, AlGhnam Suliman, Aljohani Sameera, Alqanatish Jubran T, Babiker Amir
General Pediatric, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU.
Pediatrics, King Abdulaziz Medical City Riyadh, Riyadh, SAU.
Cureus. 2022 Feb 11;14(2):e22127. doi: 10.7759/cureus.22127. eCollection 2022 Feb.
Aim The aim of this study was to assess the prevalence and clinical characterization of bocavirus infection in patients admitted with respiratory symptoms to a specialized children's hospital in Riyadh, Saudi Arabia. Methods This is a retrospective cross-sectional study that included children aged 0-14 years and was conducted over a two-year period (2017-2019). All data were gathered from an electronic information recording system, which included patients' demographics, comorbidities, clinical presentation, complication, and duration of hospitalization. Results Among all patients (11,709) admitted to King Abdullah Specialized Children's Hospital with predominant respiratory symptoms during the study period, 193 (1.6%) patients had bocavirus infections. Most of the patients were diagnosed in winter months. Cough was the primary presenting symptom (91.7%) followed by fever (83.4%). Gastrointestinal symptoms were also common (anorexia in 62% and vomiting in 39%). In 80% (n=154/193) of cases, bocavirus co-existed with other viruses, namely, human rhinovirus (45.8%), human adenovirus (31.2%), and respiratory syncytial virus type A (17.5%). Moreover, those who required oxygen supply stayed longer in the hospital (p<0.001) and were more likely to receive multiple medications such as bronchodilators (p<0.001), corticosteroids (p<0.001), and nebulized racemic epinephrine (p>0.05). Children infected with bocavirus and co-existing viruses were less likely to require oxygen supply (p<0.050). Conclusion Bocavirus infection is more common during winter months and predominantly affects respiratory and gastrointestinal systems in children. More studies are needed to evaluate the global impact of this recently recognized infection.
目的 本研究旨在评估沙特阿拉伯利雅得一家专业儿童医院收治的有呼吸道症状患者中博卡病毒感染的患病率及临床特征。方法 这是一项回顾性横断面研究，纳入了0至14岁的儿童，研究为期两年（2017 - 2019年）。所有数据均从电子信息记录系统收集，该系统包括患者的人口统计学信息、合并症、临床表现、并发症及住院时长。结果 在研究期间，阿卜杜拉国王专科医院收治的以呼吸道症状为主的所有患者（11,709例）中，193例（1.6%）患者感染了博卡病毒。大多数患者在冬季被诊断出感染。咳嗽是主要的首发症状（91.7%），其次是发热（83.4%）。胃肠道症状也很常见（厌食占62%，呕吐占39%）。在80%（n = 154/193）的病例中，博卡病毒与其他病毒共存，即人鼻病毒（45.8%）、人腺病毒（31.2%）和A型呼吸道合胞病毒（17.5%）。此外，需要吸氧的患者住院时间更长（p < 0.001），且更有可能接受多种药物治疗，如支气管扩张剂（p < 0.001）、皮质类固醇（p < 0.001）和雾化消旋肾上腺素（p > 0.05）。感染博卡病毒及共存病毒的儿童需要吸氧的可能性较小（p < 0.050）。结论 博卡病毒感染在冬季更为常见，主要影响儿童的呼吸道和胃肠道系统。需要更多研究来评估这种新发现感染的全球影响。
