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基于上转换纳米颗粒的纳米复合材料在气体治疗方面的最新进展。

Recent advances in upconversion nanoparticle-based nanocomposites for gas therapy.

作者信息

Yang Nailin, Gong Fei, Cheng Liang

机构信息

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University Suzhou 215123 China

出版信息

Chem Sci. 2021 Dec 14;13(7):1883-1898. doi: 10.1039/d1sc04413c. eCollection 2022 Feb 16.

DOI:10.1039/d1sc04413c
PMID:35308837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8848774/
Abstract

Gas therapy has attracted wide attention for the treatment of various diseases. However, a controlled gas release is highly important for biomedical applications. Upconversion nanoparticles (UCNPs) can precisely convert the long wavelength of light to ultraviolet/visible (UV/Vis) light in gas therapy for the controlled gas release owing to their unique upconversion luminescence (UCL) ability. In this review, we mainly summarized the recent progress of UCNP-based nanocomposites in gas therapy. The gases NO, O, H, HS, SO, and CO play an essential role in the physiological and pathological processes. The UCNP-based gas therapy holds great promise in cancer therapy, bacterial therapy, anti-inflammation, neuromodulation, and so on. Furthermore, the limitations and prospects of UCNP-based nanocomposites for gas therapy are also discussed.

摘要

气体疗法在各种疾病的治疗中已引起广泛关注。然而，可控的气体释放对于生物医学应用至关重要。上转换纳米粒子（UCNPs）由于其独特的上转换发光（UCL）能力，在气体疗法中可将长波长光精确转换为紫外/可见光，从而实现可控的气体释放。在这篇综述中，我们主要总结了基于UCNP的纳米复合材料在气体疗法方面的最新进展。气体一氧化氮（NO）、氧气（O）、氢气（H）、硫化氢（HS）、二氧化硫（SO）和一氧化碳（CO）在生理和病理过程中起着至关重要的作用。基于UCNP的气体疗法在癌症治疗、细菌治疗、抗炎、神经调节等方面具有广阔前景。此外，还讨论了基于UCNP的纳米复合材料用于气体疗法的局限性和前景。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f03/8848774/ca9c9280e7e4/d1sc04413c-f8.jpg
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