Pustake Manas, Tambolkar Isha, Giri Purushottam, Gandhi Charmi
Department of Internal Medicine, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, India.
Department of Internal Medicine, BJ Government Medical College and Sassoon Hospital, Pune, India.
J Family Med Prim Care. 2022 Jan;11(1):10-17. doi: 10.4103/jfmpc.jfmpc_839_21. Epub 2022 Jan 31.
In the 21 century, we have seen a total of three outbreaks by members of the coronavirus family. Although the first two outbreaks did not result in a pandemic, the third and the latest outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) culminated in a pandemic. This pandemic has been extremely significant on a social and international level. As these viruses belong to the same family, they are closely related. Despite their numerous similarities, they have slight distinctions that render them distinct from one another. The Severe Acute Respiratory Distress Syndrome and Middle East Respiratory Syndrome (MERS) cases were reported to have a very high case fatality rate of 9.5 and 34.4% respectively. In contrast, the CoVID-19 has a case fatality rate of 2.13%. Also, there are no clear medical countermeasures for these coronaviruses yet. We can cross information gaps, including cultural weapons for fighting and controlling the spread of MERS-CoV and SARS-CoV-2, and plan efficient and comprehensive defensive lines against coronaviruses that might arise or reemerge in the future by gaining a deeper understanding of these coronaviruses and the illnesses caused by them. The review thoroughly summarises the state-of-the-art information and compares the biochemical properties of these deadly coronaviruses with the clinical characteristics, laboratory features and radiological manifestations of illnesses induced by them, with an emphasis on comparing and contrasting their similarities and differences.
在21世纪，我们总共目睹了冠状病毒家族成员引发的三次疫情。尽管前两次疫情并未导致全球大流行，但第三次也是最近一次的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫情最终演变成了一场大流行。这场大流行在社会和国际层面都具有极其重大的意义。由于这些病毒属于同一家族，它们密切相关。尽管它们有许多相似之处，但也存在一些细微的差别，使它们彼此不同。据报道，严重急性呼吸窘迫综合征和中东呼吸综合征（MERS）病例的病死率分别高达9.5%和34.4%。相比之下，新冠病毒的病死率为2.13%。此外，目前还没有针对这些冠状病毒的明确医疗对策。通过更深入地了解这些冠状病毒及其引发的疾病，我们可以跨越信息鸿沟，包括对抗和控制MERS-CoV和SARS-CoV-2传播的文化手段，并规划针对未来可能出现或再次出现的冠状病毒的高效、全面的防线。这篇综述全面总结了最新信息，并将这些致命冠状病毒的生化特性与它们引发疾病的临床特征、实验室特征和影像学表现进行了比较，重点是比较和对比它们的异同。
