Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Fujian Medical University, Respirology Medicine Centre of Fujian Province, 34 Zhongshanbei Road, Licheng District, Quanzhou, China.
Department of Ultrasound Medicine, the Second Affiliated Hospital of Fujian Medical University, 34 Zhongshanbei Road, Licheng District, Quanzhou, China.
Respir Res. 2020 Aug 27;21(1):224. doi: 10.1186/s12931-020-01479-w.
Within two decades, there have emerged three highly pathogenic and deadly human coronaviruses, namely SARS-CoV, MERS-CoV and SARS-CoV-2. The economic burden and health threats caused by these coronaviruses are extremely dreadful and getting more serious as the increasing number of global infections and attributed deaths of SARS-CoV-2 and MERS-CoV. Unfortunately, specific medical countermeasures for these hCoVs remain absent. Moreover, the fast spread of misinformation about the ongoing SARS-CoV-2 pandemic uniquely places the virus alongside an annoying infodemic and causes unnecessary worldwide panic. SARS-CoV-2 shares many similarities with SARS-CoV and MERS-CoV, certainly, obvious differences exist as well. Lessons learnt from SARS-CoV and MERS-CoV, timely updated information of SARS-CoV-2 and MERS-CoV, and summarized specific knowledge of these hCoVs are extremely invaluable for effectively and efficiently contain the outbreak of SARS-CoV-2 and MERS-CoV. By gaining a deeper understanding of hCoVs and the illnesses caused by them, we can bridge knowledge gaps, provide cultural weapons for fighting and controling the spread of MERS-CoV and SARS-CoV-2, and prepare effective and robust defense lines against hCoVs that may emerge or reemerge in the future. To this end, the state-of-the-art knowledge and comparing the biological features of these lethal hCoVs and the clinical characteristics of illnesses caused by them are systematically summarized in the review.
在短短二十年内，出现了三种高致病性和致命性的人类冠状病毒，即 SARS-CoV、MERS-CoV 和 SARS-CoV-2。这些冠状病毒造成的经济负担和健康威胁极其可怕，而且随着 SARS-CoV-2 和 MERS-CoV 感染人数的不断增加和归因死亡人数的增加，情况变得更加严重。不幸的是，目前仍然缺乏针对这些 hCoV 的特定医疗对策。此外，关于正在发生的 SARS-CoV-2 大流行的错误信息迅速传播，这使得该病毒与令人讨厌的信息泛滥一起，引起了不必要的全球恐慌。SARS-CoV-2 与 SARS-CoV 和 MERS-CoV 有许多相似之处，但肯定也存在明显的差异。从 SARS-CoV 和 MERS-CoV 中吸取的教训、及时更新的 SARS-CoV-2 和 MERS-CoV 信息，以及总结的这些 hCoV 的特定知识，对于有效和高效地控制 SARS-CoV-2 和 MERS-CoV 的爆发极为宝贵。通过更深入地了解 hCoV 及其引起的疾病，我们可以弥合知识差距，为抗击和控制 MERS-CoV 和 SARS-CoV-2 的传播提供文化武器，并为未来可能出现或再次出现的 hCoV 做好有效的、强大的防御准备。为此，本文在综述中系统地总结了这些致命 hCoV 的最新知识和比较它们的生物学特征以及它们引起的疾病的临床特征。
