Dall'Oglio Federica, Fusto Carmelinda, Micali Giuseppe
All authors are with the Dermatology Clinic at University of Catania in Catania, Italy.
J Clin Aesthet Dermatol. 2022 Feb;15(2):35-39.
Rosacea hereditary predisposition has been hypothesized based on family inheritance and twin concordance. Currently, information concerning intrafamilial rosacea transmission are still limited to few generations. The aim of our study was to assess data on rosacea intrafamilial transmission spanning six generations. One-hundred and thirty patients affected by rosacea who visited our acne and rosacea clinic from June 2018 to June 2019 were consecutively enrolled in this study. During clinical evaluation, an accurate anamnesis, including familiarity across six generations, which included vertical, horizontal, and combined transmission, was performed. Affected relatives were clinically evaluated, and in those in which clinical consultation was not feasible, clinical photos were obtained. The results showed that 64 of 130 patients (49.2%) were positive for at least a family member with rosacea. In addition, 90 affected relatives (69.2%) were identified by extending the familial investigation to the whole kindred, finding a percentage of familiarity (69.2%) higher than that reported in the literature (30-50%) with a 1:1.4. ratio of patients positive for familiarity/affected relative. Our study contributes to add knowledge about intrafamilial involvement in rosacea. Extending the search to all potential affected parents and offspring of rosacea patients can promote early diagnosis along with the adoption of correct therapeutic interventions and educational programs to prevent the exposure to triggering or exacerbating factors.
酒渣鼻的遗传易感性是基于家族遗传和双胞胎一致性提出的假设。目前，关于酒渣鼻家族内传播的信息仍局限于少数几代人。我们研究的目的是评估跨越六代的酒渣鼻家族内传播数据。2018年6月至2019年6月期间到我们痤疮和酒渣鼻诊所就诊的130名酒渣鼻患者连续纳入本研究。在临床评估过程中，进行了准确的问诊，包括对六代人的家族情况调查，其中包括垂直、水平和混合传播。对受影响的亲属进行了临床评估，对于那些无法进行临床会诊的亲属，获取了临床照片。结果显示，130名患者中有64名（49.2%）至少有一名家庭成员患有酒渣鼻呈阳性。此外，通过将家族调查扩展到整个家族，确定了90名受影响的亲属（69.2%），发现家族患病率（69.2%）高于文献报道（30 - 50%），患者阳性与受影响亲属的比例为1:1.4。我们的研究有助于增加关于酒渣鼻家族内受累情况的知识。将搜索范围扩大到所有可能受影响的酒渣鼻患者的父母和后代，可以促进早期诊断，同时采取正确的治疗干预措施和教育项目，以防止接触触发或加重因素。
