莫达非尼可减轻睡眠剥夺后的神经元焦亡和认知衰退。
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation.
作者信息
Xiong Xiangyang, Zuo Yan, Cheng Lu, Yin Zhenyu, Hu Tianpeng, Guo Mengtian, Han Zhaoli, Ge Xintong, Li Wenzhu, Wang Yan, Wang Dong, Wang Conglin, Zhang Lan, Zhang Yaodan, Liu Qiang, Chen Fanglian, Lei Ping
机构信息
Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
出版信息
Front Neurosci. 2022 Mar 3;16:816752. doi: 10.3389/fnins.2022.816752. eCollection 2022.
Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD. Using a mouse model of SD, we found that modafinil improved learning and memory, reduced proinflammatory factor (IL-1β, TNF-α, and IL-6) production, and increased the expression of anti-inflammatory factors (IL-10). Modafinil treatment attenuated inflammasome activity and reduced neuronal pyroptosis involving the NLRP3/NLRP1/NLRC4-caspase-1-IL-1β pathway. In addition, modafinil induced an upregulation of brain-derived neurotrophic factor (BDNF) and synaptic activity. These results suggest that modafinil reduces neuronal pyroptosis and cognitive decline following SD. These effects should be further investigated in future studies to benefit patients with sleep disorders.
睡眠剥夺（SD）会引发全身性炎症，进而促进神经元焦亡。本研究旨在探讨抗氧化剂莫达非尼对睡眠剥夺后神经元焦亡和认知功能下降的影响。利用睡眠剥夺小鼠模型，我们发现莫达非尼改善了学习和记忆，减少了促炎因子（IL-1β、TNF-α和IL-6）的产生，并增加了抗炎因子（IL-10）的表达。莫达非尼治疗减弱了炎性小体活性，并减少了涉及NLRP3/NLRP1/NLRC4-半胱天冬酶-1-IL-1β途径的神经元焦亡。此外，莫达非尼诱导脑源性神经营养因子（BDNF）上调和突触活性增强。这些结果表明，莫达非尼可减轻睡眠剥夺后的神经元焦亡和认知功能下降。未来研究应进一步探究这些作用，以造福睡眠障碍患者。
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