Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården 4, 41296, Göteborg, Sweden.
Angew Chem Int Ed Engl. 2021 Aug 2;60(32):17378-17382. doi: 10.1002/anie.202105004. Epub 2021 Jul 1.
Modafinil, a widely used psychoactive drug, has been shown to exert a positive impact on cognition and is used to treat sleep disorders and hyperactivity. Using time-of-flight secondary ion mass spectrometric imaging, we studied the changes of brain lipids of Drosophila melanogaster induced by modafinil to gain insight into the functional mechanism of modafinil in the brain. We found that upon modafinil treatment, the abundance of phosphatidylcholine and sphingomyelin species in the central brain of Drosophila is significantly decreased, whereas the levels of phosphatidylethanolamine and phosphatidylinositol in the brains show significant enhancement compared to the control flies. The alteration of brain lipids caused by modafinil is consistent with previous studies about cognition-related drugs and offers a plausible mechanism regarding the action of modafinil in the brain as well as a potential target for the treatment of certain disorders.
莫达非尼是一种广泛使用的精神活性药物，已被证明对认知有积极影响，用于治疗睡眠障碍和多动症。本研究使用飞行时间二次离子质谱成像技术，研究了莫达非尼诱导的黑腹果蝇大脑脂质的变化，以期深入了解莫达非尼在大脑中的功能机制。我们发现，莫达非尼处理后，果蝇中枢神经系统中磷脂酰胆碱和神经鞘磷脂的丰度显著降低，而脑内的磷脂酰乙醇胺和磷脂酰肌醇水平与对照果蝇相比显著增强。莫达非尼引起的脑脂质变化与以前关于认知相关药物的研究一致，为莫达非尼在大脑中的作用机制以及治疗某些疾病的潜在靶点提供了合理的解释。
