Ford Versypt Ashlee N
Department of Chemical and Biological Engineering and Institute for Computational and Data Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Curr Opin Syst Biol. 2021 Sep;27. doi: 10.1016/j.coisb.2021.05.001. Epub 2021 May 8.
Multiscale computational modeling aims to connect the complex networks of effects at different length and/or time scales. For example, these networks often include intracellular molecular signaling, crosstalk, and other interactions between neighboring cell populations, and higher levels of emergent phenomena across different regions of tissues and among collections of tissues or organs interacting with each other in the whole body. Recent applications of multiscale modeling across intracellular, cellular, and/or tissue levels are highlighted here. These models incorporated the roles of biochemical and biomechanical modulation in processes that are implicated in the mechanisms of several diseases including fibrosis, joint and bone diseases, respiratory infectious diseases, and cancers.
多尺度计算建模旨在连接不同长度和/或时间尺度上的复杂效应网络。例如，这些网络通常包括细胞内分子信号传导、串扰以及相邻细胞群体之间的其他相互作用，以及跨组织不同区域、在全身相互作用的组织或器官集合之间出现的更高层次的现象。本文重点介绍了多尺度建模在细胞内、细胞和/或组织水平上的最新应用。这些模型纳入了生化和生物力学调节在多种疾病机制中所涉及过程中的作用，这些疾病包括纤维化、关节和骨骼疾病、呼吸道传染病以及癌症。
