Leiferman K M, Peters M S, Gleich G J
J Am Acad Dermatol. 1986 Sep;15(3):513-7. doi: 10.1016/s0190-9622(86)70203-x.
Although eosinophils are readily identified in skin tissue, their role in cutaneous disease has been obscure. Recent studies have elucidated the structure, content, and several activities of the eosinophil. The eosinophil is a potent parasite-killer cell and probably mediates damage to respiratory epithelium in bronchial asthma. We review information showing an association between cutaneous edema and eosinophil degranulation in tissue. These studies show that eosinophils release and deposit toxic granule proteins extensively in the skin despite the existence of few intact eosinophils in tissue. The evidence suggests that the eosinophil functions not only as a parasite-killer cell but also as a proinflammatory cell that may be pathophysiologically related to the development of cutaneous edema.
尽管嗜酸性粒细胞在皮肤组织中易于识别，但其在皮肤疾病中的作用一直不清楚。最近的研究阐明了嗜酸性粒细胞的结构、成分和几种活性。嗜酸性粒细胞是一种有效的杀寄生虫细胞，可能介导支气管哮喘中呼吸道上皮的损伤。我们综述了显示皮肤水肿与组织中嗜酸性粒细胞脱颗粒之间存在关联的信息。这些研究表明，尽管组织中完整的嗜酸性粒细胞很少，但嗜酸性粒细胞仍在皮肤中广泛释放和沉积有毒颗粒蛋白。证据表明，嗜酸性粒细胞不仅作为杀寄生虫细胞发挥作用，还作为一种促炎细胞，可能在病理生理上与皮肤水肿的发生有关。
