Rosenthal M
J Immunopharmacol. 1986;8(3):315-25. doi: 10.3109/08923978609026492.
A lyophilized extract from E. coli (OM-89) was studied for its immunomodulating properties and tolerance in humans. Its oral administration to healthy volunteers produced a selective increase in the active T-cell population without changes in other lymphocyte populations. A significant increase in the proliferative response to concanavalin A and phytohemagglutin was recorded, but not to pokeweed mitogen. No significant changes were observed in the serum levels of IgG, IgA and IgM. The clinical and biological tolerance of OM-89 was excellent, without any adverse side-effects or production of circulating immune complexes or of autoantibodies, while the in vitro investigation showed that it is not a mitogen. Thus in healthy subjects OM-89 seems to act mainly on the cell-mediated immune responses.
对大肠杆菌冻干提取物（OM-89）的免疫调节特性及其在人体中的耐受性进行了研究。对健康志愿者口服该提取物后，活性T细胞群体选择性增加，而其他淋巴细胞群体无变化。观察到对刀豆球蛋白A和植物血凝素的增殖反应显著增加，但对商陆有丝分裂原的反应未增加。IgG、IgA和IgM的血清水平未观察到显著变化。OM-89的临床和生物学耐受性良好，无任何不良副作用，也未产生循环免疫复合物或自身抗体，而体外研究表明它不是一种有丝分裂原。因此，在健康受试者中，OM-89似乎主要作用于细胞介导的免疫反应。
